Alternating sources of perisomatic inhibition during behavior

Barna Dudok, Peter M. Klein, Ernie Hwaun, Brian R. Lee, Zizhen Yao, Olivia Fong, John C. Bowler, Satoshi Terada, Fraser T. Sparks, Gergely G. Szabo, Jordan S. Farrell, Jim Berg, Tanya L. Daigle, Bosiljka Tasic, Jordane Dimidschstein, Gord Fishell, Attila Losonczy, Hongkui Zeng, Ivan Soltesz

Research output: Contribution to journalArticlepeer-review

Abstract

Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior.

Original languageEnglish (US)
Pages (from-to)997-1012.e9
JournalNeuron
Volume109
Issue number6
DOIs
StatePublished - Mar 17 2021

Keywords

  • brain state
  • CA1
  • CB1 receptor
  • cholecystokinin
  • GABA
  • hippocampus
  • inhibition
  • interneuron
  • locomotion
  • parvalbumin
  • Sncg

ASJC Scopus subject areas

  • Neuroscience(all)

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