Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Sam Thompson; Andrew D. Hamilton

doi:10.1039/c2ob25273b

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Sam Thompson, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Original language	English (US)
Pages (from-to)	5780-5782
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	30
DOIs	https://doi.org/10.1039/c2ob25273b
State	Published - Aug 14 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.",

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