Amphiphilic α-helix mimetics based on a benzoylurea scaffold

Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Original languageEnglish (US)
Pages (from-to)5780-5782
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number30
DOIs
StatePublished - Aug 14 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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