TY - GEN
T1 - Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs
AU - Missirlis, D.
AU - Tirelli, N.
AU - Hubbell, J. A.
PY - 2004
Y1 - 2004
N2 - The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.
AB - The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.
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M3 - Conference contribution
AN - SCOPUS:13844271499
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 353
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -