Amygdala inhibitory neurons as loci for translation in emotional memories

Prerana Shrestha, Zhe Shan, Maggie Mamcarz, Karen San Agustin Ruiz, Adam T. Zerihoun, Chien Yu Juan, Pedro M. Herrero-Vidal, Jerry Pelletier, Nathaniel Heintz, Eric Klann

Research output: Contribution to journalArticlepeer-review

Abstract

To survive in a dynamic environment, animals need to identify and appropriately respond to stimuli that signal danger1. Survival also depends on suppressing the threat-response during a stimulus that predicts the absence of threat (safety)2–5. An understanding of the biological substrates of emotional memories during a task in which animals learn to flexibly execute defensive responses to a threat-predictive cue and a safety cue is critical for developing treatments for memory disorders such as post-traumatic stress disorder5. The centrolateral amygdala is an important node in the neuronal circuit that mediates defensive responses6–9, and a key brain area for processing and storing threat memories. Here we applied intersectional chemogenetic strategies to inhibitory neurons in the centrolateral amygdala of mice to block cell-type-specific translation programs that are sensitive to depletion of eukaryotic initiation factor 4E (eIF4E) and phosphorylation of eukaryotic initiation factor 2α (p-eIF2α). We show that de novo translation in somatostatin-expressing inhibitory neurons in the centrolateral amygdala is necessary for the long-term storage of conditioned-threat responses, whereas de novo translation in protein kinase Cδ-expressing inhibitory neurons in the centrolateral amygdala is necessary for the inhibition of a conditioned response to a safety cue. Our results provide insight into the role of de novo protein synthesis in distinct inhibitory neuron populations in the centrolateral amygdala during the consolidation of long-term memories.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalNature
Volume586
Issue number7829
DOIs
StatePublished - Oct 15 2020

ASJC Scopus subject areas

  • General

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