TY - JOUR
T1 - Amylase secretion from mouse parotid and pancreas
T2 - Role of cyclic AMP and isoproterenol
AU - Malamud, Daniel
N1 - Funding Information:
This research was supported by grants from the American Cancer Society (BC-45A), the National Cystic Fibrosis Foundation, and a Career Development Award (K4 CA 70, 153-Ol) from the N.C.I. The capable technical assistance of Mrs Jean Paddock is greatfully acknowledged. I also wish to thank Drs R. A. Malt and G. W. G. Sharp for their valuable comments.
PY - 1972/9/15
Y1 - 1972/9/15
N2 - While amylase secretion from both parotid and pancreas is mediated by cyclic AMP, only parotid secretion is influence by isoproterenol. Adenyl cyclase in both tissues is stimulated by isoproterenol, but there is much less enzyme activity in preparations from pancreas. After in vivo administration of isoproterenol, parotid cyclic AMP levels are greatly elevated whereas little change is observed in pancreas.
AB - While amylase secretion from both parotid and pancreas is mediated by cyclic AMP, only parotid secretion is influence by isoproterenol. Adenyl cyclase in both tissues is stimulated by isoproterenol, but there is much less enzyme activity in preparations from pancreas. After in vivo administration of isoproterenol, parotid cyclic AMP levels are greatly elevated whereas little change is observed in pancreas.
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U2 - 10.1016/0304-4165(72)90155-9
DO - 10.1016/0304-4165(72)90155-9
M3 - Article
C2 - 4343217
AN - SCOPUS:0015510810
SN - 0304-4165
VL - 279
SP - 373
EP - 376
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 2
ER -