An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalChemical Communications
Volume53
Issue number2
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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