An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert; Sam Thompson; Andrew D. Hamilton

doi:10.1039/c6cc07787k

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert, Sam Thompson, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

Original language	English (US)
Pages (from-to)	313-316
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	2
DOIs	https://doi.org/10.1039/c6cc07787k
State	Published - 2017

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc07787k

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abstract = "A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.",

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AB - A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

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An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Abstract

ASJC Scopus subject areas

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