TY - JOUR
T1 - An actin-based nucleoskeleton involved in gene regulation and genome organization
AU - Xie, Xin
AU - Percipalle, Piergiorgio
N1 - Funding Information:
This work was partly supported by grants from the Swedish Research Council (Vetenskapsrådet) and the Swedish Cancer Society (Cancerfonden) to PP. We thank the NYU Abu Dhabi Center for Genomics and Systems Biology and the computational platform provided by NYUAD HPC team for technical help. The authors would also like to acknowledge support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure.
Funding Information:
This work was partly supported by grants from the Swedish Research Council (Vetenskapsr?det) and the Swedish Cancer Society (Cancerfonden) to PP. We thank the NYU Abu Dhabi Center for Genomics and Systems Biology and the computational platform provided by NYUAD HPC team for technical help. The authors would also like to acknowledge support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/11/25
Y1 - 2018/11/25
N2 - In eukaryotic cells gene regulation is dependent on global genome organization. This is achieved, in response to favorable environmental conditions, through spatial redistribution of chromatin and changes in global epigenetic levels. This eventually drives movement of gene-rich chromatin loops and formation of DNA loops, consolidating neighborhoods of gene expression and silencing. One of the challenges for future work is to examine how these neighborhoods are formed and whether they host genes involved in the same cellular functions for sustained expression or silencing over time. In the present review, we summarize evidence that actin and actin-associated proteins regulate gene activity. Furthermore we discuss how these specific nuclear tasks in which actin is engaged are important to organize and consolidate the mammalian genome, ensuring gene activation and repression of gene programs important to establish cellular identity. We propose that these mechanisms are essential to control cellular development and differentiation.
AB - In eukaryotic cells gene regulation is dependent on global genome organization. This is achieved, in response to favorable environmental conditions, through spatial redistribution of chromatin and changes in global epigenetic levels. This eventually drives movement of gene-rich chromatin loops and formation of DNA loops, consolidating neighborhoods of gene expression and silencing. One of the challenges for future work is to examine how these neighborhoods are formed and whether they host genes involved in the same cellular functions for sustained expression or silencing over time. In the present review, we summarize evidence that actin and actin-associated proteins regulate gene activity. Furthermore we discuss how these specific nuclear tasks in which actin is engaged are important to organize and consolidate the mammalian genome, ensuring gene activation and repression of gene programs important to establish cellular identity. We propose that these mechanisms are essential to control cellular development and differentiation.
KW - Chromatin remodeling
KW - Differentiation
KW - Epigenetic modification
KW - Genome organization
KW - Nuclear actin
KW - Nuclear myosin
KW - Nucleoskeleton
KW - Transcriptional regulation
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U2 - 10.1016/j.bbrc.2017.11.206
DO - 10.1016/j.bbrc.2017.11.206
M3 - Article
C2 - 29203242
AN - SCOPUS:85037648144
SN - 0006-291X
VL - 506
SP - 378
EP - 386
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -