TY - JOUR
T1 - An analysis of dishabituation and sensitization of the gill-withdrawal reflex in aplysia
AU - Carew, Thomas J.
AU - Castellucci, Vincent F.
AU - Kandel, Eric R.
N1 - Funding Information:
We thank Drs. Irving Kupfermann, Earl Mayeri, Harold Pinsker and Wm. Alden Spencer for their helpful comments on an earlier draft of this paper, and Miss Kathrin Hilten for her continued and excellent assistance with the iflustra-tions. Dr. Kupfermann also kindly permitted us to use Figure 6A from an unpublished collaborative experiment. This research was supported by NIMH Grant MH 15980 and NS 09361-01. T. Carew was supported by a postdoctoral fellowship (MH 08638-06) awarded by the Department of Psychiatry, N.Y.U. Medical Center. V. Castellucci was supported by a Canadian Medical Council fellowship (100-2C-88). E. Kandel was supported by a Career Scientist Award No. 5K5-MH 18,558-03 from NIMH.
PY - 1971
Y1 - 1971
N2 - We have used a combined behavioral and cellular neurophysiological analysis to examine the relationship of sensitization to dishabituation of the gill-withdrawal reflex in Aplysia. The reflex withdrawal of the gill to tactile stimulation of the siphon or the purple gland (at the edge of the mantle shelf) shows habituation, dishabituation and sensitization. We have found that the purple gland and siphon provide independent afferent pathways each capable of eliciting the gill-withdrawal reflex. Habituation of one pathway did not affect the other, but a common 'dishabituatory' stimulus produced dishabituation of the habituated pathway as well as sensitization of the non-habituated pathway. These findings support the idea that dishabituation is not due to the removal of habituation but is an independent facilitation superimposed upon habituation. Our neurophysiological analysis showed that, on the cellular level, the neural correlates of sensitization and dishabituation are different reflections of a common heterosynaptic facilitatory process involving an incteased effectiveness of excitatory synaptic transmission at the synapse between sensory and motor neurons.
AB - We have used a combined behavioral and cellular neurophysiological analysis to examine the relationship of sensitization to dishabituation of the gill-withdrawal reflex in Aplysia. The reflex withdrawal of the gill to tactile stimulation of the siphon or the purple gland (at the edge of the mantle shelf) shows habituation, dishabituation and sensitization. We have found that the purple gland and siphon provide independent afferent pathways each capable of eliciting the gill-withdrawal reflex. Habituation of one pathway did not affect the other, but a common 'dishabituatory' stimulus produced dishabituation of the habituated pathway as well as sensitization of the non-habituated pathway. These findings support the idea that dishabituation is not due to the removal of habituation but is an independent facilitation superimposed upon habituation. Our neurophysiological analysis showed that, on the cellular level, the neural correlates of sensitization and dishabituation are different reflections of a common heterosynaptic facilitatory process involving an incteased effectiveness of excitatory synaptic transmission at the synapse between sensory and motor neurons.
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U2 - 10.3109/00207457109146995
DO - 10.3109/00207457109146995
M3 - Article
C2 - 4347410
AN - SCOPUS:0015100195
SN - 0020-7454
VL - 2
SP - 79
EP - 98
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 2
ER -