An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene

Christian A. Kuttruff; Simon Geiger; Mesut Cakmak; Peter Mayer; Dirk Trauner

doi:10.1021/ol203437a

An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene

Christian A. Kuttruff, Simon Geiger, Mesut Cakmak, Peter Mayer, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.

Original language	English (US)
Pages (from-to)	1070-1073
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	4
DOIs	https://doi.org/10.1021/ol203437a
State	Published - Feb 17 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol203437a

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abstract = "A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.",

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AU - Mayer, Peter

AU - Trauner, Dirk

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An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene

Abstract

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