An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene

Christian A. Kuttruff, Simon Geiger, Mesut Cakmak, Peter Mayer, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.

Original languageEnglish (US)
Pages (from-to)1070-1073
Number of pages4
JournalOrganic Letters
Volume14
Issue number4
DOIs
StatePublished - Feb 17 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Kuttruff, C. A., Geiger, S., Cakmak, M., Mayer, P., & Trauner, D. (2012). An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene. Organic Letters, 14(4), 1070-1073. https://doi.org/10.1021/ol203437a