TY - JOUR

T1 - An asymptotic formula for boundary potential perturbations in a semilinear elliptic equation related to cardiac electrophysiology

AU - Beretta, Elena

AU - Cerutti, M. Cristina

AU - Manzoni, Andrea

AU - Pierotti, Dario

N1 - Publisher Copyright:
© 2016 World Scientific Publishing Company.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - In this paper, we provide a representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction in a simplified monodomain model describing the electrical activity of the heart. We derive such a result in the case of a nonlinear problem. Our long-term goal is the solution of the inverse problem related to the detection of regions affected by heart ischemic disease, whose position and size are unknown. We model the presence of ischemic regions in the form of small inhomogeneities. This leads to the study of a boundary value problem for a semilinear elliptic equation. We first analyze the well-posedness of the problem establishing some key energy estimates. These allow us to derive rigorously an asymptotic formula of the boundary potential perturbation due to the presence of the inhomogeneities, following an approach similar to the one introduced by Capdeboscq and Vogelius in [A general representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction, Math. Model. Numer. Anal. 37 (2003) 159-173] in the case of the linear conductivity equation. Finally, we propose some ideas of the reconstruction procedure that might be used to detect the inhomogeneities.

AB - In this paper, we provide a representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction in a simplified monodomain model describing the electrical activity of the heart. We derive such a result in the case of a nonlinear problem. Our long-term goal is the solution of the inverse problem related to the detection of regions affected by heart ischemic disease, whose position and size are unknown. We model the presence of ischemic regions in the form of small inhomogeneities. This leads to the study of a boundary value problem for a semilinear elliptic equation. We first analyze the well-posedness of the problem establishing some key energy estimates. These allow us to derive rigorously an asymptotic formula of the boundary potential perturbation due to the presence of the inhomogeneities, following an approach similar to the one introduced by Capdeboscq and Vogelius in [A general representation formula for boundary voltage perturbations caused by internal conductivity inhomogeneities of low volume fraction, Math. Model. Numer. Anal. 37 (2003) 159-173] in the case of the linear conductivity equation. Finally, we propose some ideas of the reconstruction procedure that might be used to detect the inhomogeneities.

KW - Asymptotic expansion

KW - Elliptic semilinear equation

KW - Inverse problem

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U2 - 10.1142/S0218202516500135

DO - 10.1142/S0218202516500135

M3 - Article

AN - SCOPUS:84955065178

SN - 0218-2025

VL - 26

SP - 645

EP - 670

JO - Mathematical Models and Methods in Applied Sciences

JF - Mathematical Models and Methods in Applied Sciences

IS - 4

ER -