An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output during C. elegans Development

Natalia Stec, Katja Doerfel, Kelly Hills-Muckey, Victoria M. Ettorre, Sevinc Ercan, Wolfgang Keil, Christopher M. Hammell

Research output: Contribution to journalArticlepeer-review

Abstract

Stec et al. describe a novel transcriptional priming mechanism where BLMP-1, a highly conserved ZnF transcription factor, decompacts chromatin at specific target loci hours prior to gene expression. This mechanism regulates the transcriptional output of many key genes that control cell fate specification during post-embryonic development.

Original languageEnglish (US)
JournalCurrent Biology
DOIs
StateAccepted/In press - 2021

Keywords

  • oscillatory transcription
  • pioneer transcription factor
  • temporal patterning
  • transcriptional activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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