An evaluation of anti-oxidative protection for cells against atmospheric pressure cold plasma treatment

Ruonan Ma; Hongqing Feng; Fangting Li; Yongdong Liang; Qian Zhang; Weidong Zhu; Jue Zhang; Kurt H. Becker; Jing Fang

doi:10.1063/1.3693165

An evaluation of anti-oxidative protection for cells against atmospheric pressure cold plasma treatment

Ruonan Ma, Hongqing Feng, Fangting Li, Yongdong Liang, Qian Zhang, Weidong Zhu, Jue Zhang, Kurt H. Becker, Jing Fang

Research output: Contribution to journal › Article › peer-review

Abstract

With the development of plasma medicine, safety issues are emerging as a serious concern. In this study, both intracellular (genetic engineering) and extracellular (scavengers) measures were tested in an effort to determine the best protection for cells against plasma-induced oxidative stress. All results of immediate reactive species detection, short term survival and long term proliferation, suggest that intracellular pathways are superior in reducing oxidative stress and cell death. This work provides a potential mechanism to enhance safety and identifies precautionary measures that should be taken in future clinical applications of plasmas.

Original language	English (US)
Article number	123701
Journal	Applied Physics Letters
Volume	100
Issue number	12
DOIs	https://doi.org/10.1063/1.3693165
State	Published - Mar 19 2012

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.3693165

Cite this

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title = "An evaluation of anti-oxidative protection for cells against atmospheric pressure cold plasma treatment",

abstract = "With the development of plasma medicine, safety issues are emerging as a serious concern. In this study, both intracellular (genetic engineering) and extracellular (scavengers) measures were tested in an effort to determine the best protection for cells against plasma-induced oxidative stress. All results of immediate reactive species detection, short term survival and long term proliferation, suggest that intracellular pathways are superior in reducing oxidative stress and cell death. This work provides a potential mechanism to enhance safety and identifies precautionary measures that should be taken in future clinical applications of plasmas.",

author = "Ruonan Ma and Hongqing Feng and Fangting Li and Yongdong Liang and Qian Zhang and Weidong Zhu and Jue Zhang and Becker, {Kurt H.} and Jing Fang",

note = "Funding Information: This research is supported by Bioelectrics Inc. (USA), MST Program of International Science, the Fundamental Research Funds for the Central Universities and Technology Cooperation (under Grant No. 2009DFB30370: “Cold plasma induced biological effect and its clinical application studies”) and National Basic Research Program (No. 2007CB935602).",

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AU - Ma, Ruonan

AU - Feng, Hongqing

AU - Li, Fangting

AU - Liang, Yongdong

AU - Zhang, Qian

AU - Zhu, Weidong

AU - Zhang, Jue

AU - Becker, Kurt H.

AU - Fang, Jing

N1 - Funding Information: This research is supported by Bioelectrics Inc. (USA), MST Program of International Science, the Fundamental Research Funds for the Central Universities and Technology Cooperation (under Grant No. 2009DFB30370: “Cold plasma induced biological effect and its clinical application studies”) and National Basic Research Program (No. 2007CB935602).

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Y1 - 2012/3/19

N2 - With the development of plasma medicine, safety issues are emerging as a serious concern. In this study, both intracellular (genetic engineering) and extracellular (scavengers) measures were tested in an effort to determine the best protection for cells against plasma-induced oxidative stress. All results of immediate reactive species detection, short term survival and long term proliferation, suggest that intracellular pathways are superior in reducing oxidative stress and cell death. This work provides a potential mechanism to enhance safety and identifies precautionary measures that should be taken in future clinical applications of plasmas.

AB - With the development of plasma medicine, safety issues are emerging as a serious concern. In this study, both intracellular (genetic engineering) and extracellular (scavengers) measures were tested in an effort to determine the best protection for cells against plasma-induced oxidative stress. All results of immediate reactive species detection, short term survival and long term proliferation, suggest that intracellular pathways are superior in reducing oxidative stress and cell death. This work provides a potential mechanism to enhance safety and identifies precautionary measures that should be taken in future clinical applications of plasmas.

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An evaluation of anti-oxidative protection for cells against atmospheric pressure cold plasma treatment

Abstract

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