An extension of Kendall's coefficient of concordance to bivariate interval censored data

Rebecca A. Betensky, Dianne M. Finkelstein

Research output: Contribution to journalArticle

Abstract

Non-parametric tests of independence, as well as accompanying measures of association, are essential tools for the analysis of bivariate data. Such tests and measures have been developed for uncensored and right censored failure time data, but have not been developed for interval censored failure time data. Bivariate interval censored data arise in AIDS studies in which screening tests for early signs of viral and bacterial infection are done at clinic visits. Because of missed clinic visits, the actual times of first positive screening tests are interval censored. To handle such data, we propose an extension of Kendall's coefficient of concordance. We apply it to data from an AIDS study that recorded times of shedding of cytomegalovirus (CMV) and times of colonization of mycobacterium avium complex (MAC). We examine the performance of our proposed measure through a simulation study.

Original languageEnglish (US)
Pages (from-to)3101-3109
Number of pages9
JournalStatistics in Medicine
Volume18
Issue number22
DOIs
StatePublished - Nov 30 1999

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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