TY - JOUR
T1 - An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory
AU - Fall, Christopher P.
AU - Rinzel, John
N1 - Funding Information:
Acknowledgments This work was supported by NIH MH 64611 to C.P.F. The authors also acknowledge the stimulating scientific environment and interactions at the NSF Mathematical Biosciences Institute, Ohio State University
PY - 2006/2
Y1 - 2006/2
N2 - We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca2+ handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca2+ subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full "hybrid" network sustains IP3-dependent persistent ("bump") activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise - its position does not drift with time.
AB - We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca2+ handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca2+ subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full "hybrid" network sustains IP3-dependent persistent ("bump") activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise - its position does not drift with time.
KW - Calcium signaling
KW - Computational model
KW - Inositol 1,4,5 trisphosphate
KW - Neuromodulators
KW - Persistent activity
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=33646086238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646086238&partnerID=8YFLogxK
U2 - 10.1007/s10827-006-4791-8
DO - 10.1007/s10827-006-4791-8
M3 - Article
C2 - 16511655
AN - SCOPUS:33646086238
SN - 0929-5313
VL - 20
SP - 97
EP - 107
JO - Journal of Computational Neuroscience
JF - Journal of Computational Neuroscience
IS - 1
ER -