An optimal hydrogen-bond surrogate for α-helices

Stephen T. Joy; Paramjit S. Arora

doi:10.1039/c6cc01104g

An optimal hydrogen-bond surrogate for α-helices

Stephen T. Joy, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.

Original language	English (US)
Pages (from-to)	5738-5741
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	33
DOIs	https://doi.org/10.1039/c6cc01104g
State	Published - Apr 28 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc01104g

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abstract = "Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.",

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An optimal hydrogen-bond surrogate for α-helices

Abstract

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