An optimal hydrogen-bond surrogate for α-helices

Stephen T. Joy, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.

Original languageEnglish (US)
Pages (from-to)5738-5741
Number of pages4
JournalChemical Communications
Issue number33
StatePublished - Apr 28 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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