An optimization principle for initiation and adaptation of biological transport networks

Dan Hu, David Cai

Research output: Contribution to journalArticle

Abstract

Structural optimization of biological transport networks, such as leaf venation and blood vessel systems, can be regarded as a consequence of natural selection. Many studies have examined the important question of whether an adaptation dynamics of edges can be responsible for structural optimization. However, what role the initiation process plays in structural optimization remains to be clarified. Here we propose an optimization principle that potentially underlies common mechanisms that drive the formation of biological transport networks. Associated with the optimization principle is an adaptation dynamics of cell polarization that unifies initiation processes and segment formation of transport networks. In our model, the competition between the reduction of transport energy cost and the reduction of material and metabolic consumptions is sufficient to induce optimal structures: a tree-like network as well as loops under different states of fluctuating drives.

Original languageEnglish (US)
Pages (from-to)1427-1436
Number of pages10
JournalCommunications in Mathematical Sciences
Volume17
Issue number5
DOIs
StatePublished - 2019

Keywords

  • Adaptation
  • Biological transport networks
  • Initiation

ASJC Scopus subject areas

  • Mathematics(all)
  • Applied Mathematics

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