An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS)

Y. Chen; F. Wu; M. L. Liu; S. Segers; H. Ahsan; F. Parvez; V. Slavkovich; D. Levy; J. H. Graziano; A. Van Geen; T. Islam; A. Ahmed; M. Rakibuz-Zaman; R. Hasan; G. Sarwar

doi:10.1201/b12522-67

An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS)

Y. Chen, F. Wu, M. L. Liu, S. Segers, H. Ahsan, F. Parvez, V. Slavkovich, D. Levy, J. H. Graziano, A. Van Geen, T. Islam, A. Ahmed, M. Rakibuz-Zaman, R. Hasan, G. Sarwar

Urban Initiative

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Epidemiologic studies have linked arsenic exposure from drinking water to elevated risks of CardioVascular Disease (CVD). However, the underlying mechanism by which arsenic may lead to CVD is unclear. We conducted a series of cross-sectional and prospective analyses using data from the Health Effects of arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh. We found that chronic arsenic exposure from drinking water was positively associated with plasma levels of sVCAM-1 and the association was stronger in people with higher body mass index; past long-term arsenic exposure was related to subsequent QT-interval prolongation, especially in women; the proportion of monomethylarsonic acid in urine was positively associated with heart disease risk, especially among smokers. Our results indicate that mechanisms underlying arsenic exposure-related CVD may involve inflammation, endothelial dysfunction, electrocardiogram abnormalities, and incomplete arsenic methylation capacity.

Original language	English (US)
Title of host publication	Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress
Subtitle of host publication	Arsenic in the Environment
Publisher	Taylor and Francis - Balkema
Pages	165-167
Number of pages	3
ISBN (Print)	9780415637633
DOIs	https://doi.org/10.1201/b12522-67
State	Published - 2012
Event	4th International Congress on Arsenic in the Environment, As 2012 - Cairns, QLD, Australia Duration: Jul 22 2012 → Jul 27 2012

Publication series

Name	Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment

Other

Other	4th International Congress on Arsenic in the Environment, As 2012
Country/Territory	Australia
City	Cairns, QLD
Period	7/22/12 → 7/27/12

ASJC Scopus subject areas

Environmental Chemistry
Pollution

Access to Document

10.1201/b12522-67

Cite this

Chen, Y., Wu, F., Liu, M. L., Segers, S., Ahsan, H., Parvez, F., Slavkovich, V., Levy, D., Graziano, J. H., Van Geen, A., Islam, T., Ahmed, A., Rakibuz-Zaman, M., Hasan, R., & Sarwar, G. (2012). An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment (pp. 165-167). (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment). Taylor and Francis - Balkema. https://doi.org/10.1201/b12522-67

An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). / Chen, Y.; Wu, F.; Liu, M. L. et al.
Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. Taylor and Francis - Balkema, 2012. p. 165-167 (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chen, Y, Wu, F, Liu, ML, Segers, S, Ahsan, H, Parvez, F, Slavkovich, V, Levy, D, Graziano, JH, Van Geen, A, Islam, T, Ahmed, A, Rakibuz-Zaman, M, Hasan, R & Sarwar, G 2012, An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). in Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment, Taylor and Francis - Balkema, pp. 165-167, 4th International Congress on Arsenic in the Environment, As 2012, Cairns, QLD, Australia, 7/22/12. https://doi.org/10.1201/b12522-67

Chen Y, Wu F, Liu ML, Segers S, Ahsan H, Parvez F et al. An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. Taylor and Francis - Balkema. 2012. p. 165-167. (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment). doi: 10.1201/b12522-67

Chen, Y. ; Wu, F. ; Liu, M. L. et al. / An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment. Taylor and Francis - Balkema, 2012. pp. 165-167 (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment).

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AU - Ahsan, H.

AU - Parvez, F.

AU - Slavkovich, V.

AU - Levy, D.

AU - Graziano, J. H.

AU - Van Geen, A.

AU - Islam, T.

AU - Ahmed, A.

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AU - Hasan, R.

AU - Sarwar, G.

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AB - Epidemiologic studies have linked arsenic exposure from drinking water to elevated risks of CardioVascular Disease (CVD). However, the underlying mechanism by which arsenic may lead to CVD is unclear. We conducted a series of cross-sectional and prospective analyses using data from the Health Effects of arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh. We found that chronic arsenic exposure from drinking water was positively associated with plasma levels of sVCAM-1 and the association was stronger in people with higher body mass index; past long-term arsenic exposure was related to subsequent QT-interval prolongation, especially in women; the proportion of monomethylarsonic acid in urine was positively associated with heart disease risk, especially among smokers. Our results indicate that mechanisms underlying arsenic exposure-related CVD may involve inflammation, endothelial dysfunction, electrocardiogram abnormalities, and incomplete arsenic methylation capacity.

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An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS)

Abstract

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ASJC Scopus subject areas

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