An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS)

Y. Chen, F. Wu, M. L. Liu, S. Segers, H. Ahsan, F. Parvez, V. Slavkovich, D. Levy, J. H. Graziano, A. Van Geen, T. Islam, A. Ahmed, M. Rakibuz-Zaman, R. Hasan, G. Sarwar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Epidemiologic studies have linked arsenic exposure from drinking water to elevated risks of CardioVascular Disease (CVD). However, the underlying mechanism by which arsenic may lead to CVD is unclear. We conducted a series of cross-sectional and prospective analyses using data from the Health Effects of arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh. We found that chronic arsenic exposure from drinking water was positively associated with plasma levels of sVCAM-1 and the association was stronger in people with higher body mass index; past long-term arsenic exposure was related to subsequent QT-interval prolongation, especially in women; the proportion of monomethylarsonic acid in urine was positively associated with heart disease risk, especially among smokers. Our results indicate that mechanisms underlying arsenic exposure-related CVD may involve inflammation, endothelial dysfunction, electrocardiogram abnormalities, and incomplete arsenic methylation capacity.

Original languageEnglish (US)
Title of host publicationUnderstanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress
Subtitle of host publicationArsenic in the Environment
PublisherTaylor and Francis - Balkema
Pages165-167
Number of pages3
ISBN (Print)9780415637633
DOIs
StatePublished - 2012
Event4th International Congress on Arsenic in the Environment, As 2012 - Cairns, QLD, Australia
Duration: Jul 22 2012Jul 27 2012

Publication series

NameUnderstanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment

Other

Other4th International Congress on Arsenic in the Environment, As 2012
CountryAustralia
CityCairns, QLD
Period7/22/127/27/12

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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    Chen, Y., Wu, F., Liu, M. L., Segers, S., Ahsan, H., Parvez, F., Slavkovich, V., Levy, D., Graziano, J. H., Van Geen, A., Islam, T., Ahmed, A., Rakibuz-Zaman, M., Hasan, R., & Sarwar, G. (2012). An update of findings on arsenic exposure and cardiovascular disease outcomes from the Health Effects of Arsenic Longitudinal Study (HEALS). In Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment (pp. 165-167). (Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment). Taylor and Francis - Balkema. https://doi.org/10.1201/b12522-67