Analgesic efficacy and safety of an: Intraoral lidocaine patch

Elliot V. Hersh, Milton I. Houpt, Stephen A. Cooper, Roy S. Feldman, Mark S. Wolff, Lawrence M. Levin

Research output: Contribution to journalArticlepeer-review


The effectiveness of intraoral lidocaine patches was tested by asking participants to rate the pain experienced after insertions of a 25-gauge needle. Needlesticks were performed at baseline and at various time points after patch placement. Each needlestick included contact with the periosteum. Lidocaine patches achieved significantly better analgesia than the placebo within 2.5 to five minutes after placement. Drug-related side effects were minimal and venous blood levels of lidocaine were low, averaging 10 to 14 times less than those achieved with a typical injection of lidocaine plus epinephrine. The authors conclude that the lidocaine patches used in this study are effective and safe in reducing needle insertion pain in adults.

Original languageEnglish (US)
Pages (from-to)1626-1634
Number of pages9
JournalJournal of the American Dental Association
Issue number11
StatePublished - Nov 1996

ASJC Scopus subject areas

  • General Dentistry


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