Analysis and classification of optical tomographic images of rheumatoid fingers with ANOVA and discriminate analysis

Ludguier D. Montejo, Hyun K. Kim, Yrjö Häme, Jingfei Jia, Julio D. Montejo, Uwe J. Netz, Sabine Blaschke, Paul Zwaka, Gerhard A. Müeller, Jürgen Beuthan, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We present a study on the effectiveness of computer-aided diagnosis (CAD) of rheumatoid arthritis (RA) from frequency-domain diffuse optical tomographic (FDOT) images. FDOT is used to obtain the distribution of tissue optical properties. Subsequently, the non-parametric Kruskal-Wallis ANOVA test is employed to verify statistically significant differences between the optical parameters of patients affected by RA and healthy volunteers. Furthermore, quadratic discriminate analysis (QDA) of the absorption (μa) and scattering (μa or μ's) distributions is used to classify subjects as affected or not affected by RA. We evaluate the classification efficiency by determining the sensitivity (Se), specificity (Sp), and the Youden index (Y). We find that combining features extracted from μa and μa or μ's images allows for more accurate classification than when μa or μa or μ's features are considered individually on their own. Combining μa and μa or μ's features yields values of up to Y = 0.75 (Se = 0.84 and Sp = 0.91). The best results when μa or μ's features are considered individually are Y = 0.65 (Se = 0.85 and Sp = 0.80) and Y = 0.70 (Se = 0.80 and Sp = 0.90), respectively.

    Original languageEnglish (US)
    Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems IX
    DOIs
    StatePublished - 2011
    EventAdvanced Biomedical and Clinical Diagnostic Systems IX - San Francisco, CA, United States
    Duration: Jan 23 2011Jan 25 2011

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume7890
    ISSN (Print)1605-7422

    Conference

    ConferenceAdvanced Biomedical and Clinical Diagnostic Systems IX
    CountryUnited States
    CitySan Francisco, CA
    Period1/23/111/25/11

    Keywords

    • ANOVA
    • computer aided diagnosis
    • Diffuse optical tomography
    • discriminate analysis
    • rheumatoid arthritis

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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