Analysis of brain white matter via fiber tract modeling

Guido Gerig, Sylvain Gouttard, Isabelle Corouge

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    White matter fiber bundles of the human brain form a spatial pattern defined by the anatomical and functional architecture. Tractography applied to the tensor field in diffusion tensor imaging (DTI) results in sets of streamlines which can be associated with major fiber tracts. Comparison of fiber tract properties across subjects needs comparison at corresponding anatomical locations. Moreover, clinical analysis studying fiber tract disruption and integrity requires analysis along tracts and within crosssections, which is hard to accomplish by conventional region of interest and voxel-based analysis. We propose a new framework for MR DTI analysis that includes tractography, fiber clustering, alignment via local shape parametrization and diffusion analysis across and along tracts. Feasibility is shown with the uncinate fasciculus and the cortico-spinal tracts. The extended set of features including fiber tract geometry and diffusion properties might lead to an improved understanding of diffusion properties and its association to normal/abnormal brain development.

    Original languageEnglish (US)
    Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
    Pages4421-4424
    Number of pages4
    Volume26 VI
    StatePublished - 2004
    EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
    Duration: Sep 1 2004Sep 5 2004

    Other

    OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
    CountryUnited States
    CitySan Francisco, CA
    Period9/1/049/5/04

    ASJC Scopus subject areas

    • Bioengineering

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  • Cite this

    Gerig, G., Gouttard, S., & Corouge, I. (2004). Analysis of brain white matter via fiber tract modeling. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 VI, pp. 4421-4424)