Analysis of co-aggregation of cancer based on registry data

Abigail G. Matthews, Rebecca A. Betensky, Hoda Anton-Culver, Deborah Bowen, Constance Griffin, Claudine Isaacs, Carol Kasten, Geraldine Mineau, Susan Nayfield, Joellen Schildkraut, Louise Strong, Barbara Weber, Dianne M. Finkelstein

Research output: Contribution to journalArticlepeer-review


Objective: An exploratory analysis of co-aggregation of cancers using registry-based data. Methods: We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment. Results: We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01). Conclusion: This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCommunity Genetics
Issue number2
StatePublished - Apr 2006


  • Association
  • Cancer Genetics Network
  • Familial aggregation
  • Family study

ASJC Scopus subject areas

  • Genetics(clinical)


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