TY - JOUR
T1 - Analysis of co-aggregation of cancer based on registry data
AU - Matthews, Abigail G.
AU - Betensky, Rebecca A.
AU - Anton-Culver, Hoda
AU - Bowen, Deborah
AU - Griffin, Constance
AU - Isaacs, Claudine
AU - Kasten, Carol
AU - Mineau, Geraldine
AU - Nayfield, Susan
AU - Schildkraut, Joellen
AU - Strong, Louise
AU - Weber, Barbara
AU - Finkelstein, Dianne M.
PY - 2006/4
Y1 - 2006/4
N2 - Objective: An exploratory analysis of co-aggregation of cancers using registry-based data. Methods: We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment. Results: We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01). Conclusion: This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.
AB - Objective: An exploratory analysis of co-aggregation of cancers using registry-based data. Methods: We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment. Results: We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01). Conclusion: This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.
KW - Association
KW - Cancer Genetics Network
KW - Familial aggregation
KW - Family study
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U2 - 10.1159/000091485
DO - 10.1159/000091485
M3 - Article
C2 - 16612058
AN - SCOPUS:33645713903
SN - 1662-4246
VL - 9
SP - 87
EP - 92
JO - Public Health Genomics
JF - Public Health Genomics
IS - 2
ER -