Abstract
Familial aggregation studies are a common first step in the identification of genetic determinants of disease. If aggregation is found, more refined genetic studies may be undertaken. Complex ascertainment schemes are frequently employed to ensure that the sample contains a sufficient number of families with multiple affected members, as required to detect aggregation. For example, an eligibility criterion for a family might be that both the mother and daughter have disease. Adjustments must be made for ascertainment to avoid bias. We propose adjusting for complex ascertainment schemes through a joint model for the outcomes of disease and ascertainment. This approach improves upon previous simplifying assumptions regarding the ascertainment process.
Original language | English (US) |
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Pages (from-to) | 5076-5092 |
Number of pages | 17 |
Journal | Statistics in Medicine |
Volume | 27 |
Issue number | 24 |
DOIs | |
State | Published - Dec 30 2008 |
Keywords
- Ascertainment bias
- Familial aggregation
- Quadratic exponential model
ASJC Scopus subject areas
- Epidemiology
- Statistics and Probability