TY - JOUR
T1 - Analytical approach to the protein design problem
AU - Kussell, Edo L.
AU - Shakhnovich, Eugene I.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a hierarchy of structures, from most to least designable, and show that this hierarchy depends on the potential that is used.
AB - We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a hierarchy of structures, from most to least designable, and show that this hierarchy depends on the potential that is used.
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U2 - 10.1103/PhysRevLett.83.4437
DO - 10.1103/PhysRevLett.83.4437
M3 - Article
AN - SCOPUS:0000741681
SN - 0031-9007
VL - 83
SP - 4437
EP - 4440
JO - Physical Review Letters
JF - Physical Review Letters
IS - 21
ER -