Analytical approach to the protein design problem

Edo L. Kussell, Eugene I. Shakhnovich

Research output: Contribution to journalArticlepeer-review


We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a hierarchy of structures, from most to least designable, and show that this hierarchy depends on the potential that is used.

Original languageEnglish (US)
Pages (from-to)4437-4440
Number of pages4
JournalPhysical Review Letters
Issue number21
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • General Physics and Astronomy


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