Analyzing imaging biomarkers for traumatic brain injury using 4d modeling of longitudinal MRI

Bo Wang, Marcel Prastawa, Andrei Irimia, Micah C. Chambers, Neda Sadeghi, Paul M. Vespa, John D. Van Horn, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Quantitative imaging biomarkers are important for assessment of impact, recovery and treatment efficacy in patients with traumatic brain injury (TBI). To our knowledge, the identification of such biomarkers characterizing disease progress and recovery has been insufficiently explored in TBI due to difficulties in registration of baseline and follow-up data and automatic segmentation of tissue and lesions from multimodal, longitudinal MR image data. We propose a new methodology for computing imaging biomarkers in TBI by extending a recently proposed spatiotemporal 4D modeling approach in order to compute quantitative features of tissue change. The proposed method computes surface-based and voxel-based measurements such as cortical thickness, volume changes, and geometric deformation. We analyze the potential for clinical use of these biomarkers by correlating them with TBI-specific patient scores at the level of the whole brain and of individual regions. Our preliminary results indicate that the proposed voxel-based biomarkers are correlated with clinical outcomes.

    Original languageEnglish (US)
    Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
    Subtitle of host publicationFrom Nano to Macro
    Pages1392-1395
    Number of pages4
    DOIs
    StatePublished - 2013
    Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
    Duration: Apr 7 2013Apr 11 2013

    Publication series

    NameProceedings - International Symposium on Biomedical Imaging
    ISSN (Print)1945-7928
    ISSN (Electronic)1945-8452

    Other

    Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
    CountryUnited States
    CitySan Francisco, CA
    Period4/7/134/11/13

    Keywords

    • Imaging biomarkers
    • clinical outcome
    • correlation analysis
    • longitudinal MRI

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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