TY - JOUR
T1 - Anatomical localization of β1 integrin-like immunoreactivity in rat brain
AU - Grooms, Sonja Y.
AU - Terracio, Louis
AU - Jones, Leslie Sargent
PY - 1993/8
Y1 - 1993/8
N2 - β1 Integrin-like immunoreactivity was localized in rat brain using a polyclonal antibody raised in rabbit against rat liver β1 integrin. One-dimensional immunoblotting of whole rat brain membranes indicated that this antiserum recognized a single molecular species at 116,000 Mr, indicative of rat β1 integrins. Specific staining of β1 integrin-like immunoreactivity was found in the vascular structures of the brain, including microvessels, the ventricular ependymal cells, and pia mater. The pineal gland stained densely, and diffuse staining was present throughout the gray matter of the brain. This diffuse staining had a patterned appearance in certain structures, such as the apical dendritic field of CA1 in hippocampus, and occasional labeling of astrocytes, verified by labeling with GFAP on adjacent sections, was noted.
AB - β1 Integrin-like immunoreactivity was localized in rat brain using a polyclonal antibody raised in rabbit against rat liver β1 integrin. One-dimensional immunoblotting of whole rat brain membranes indicated that this antiserum recognized a single molecular species at 116,000 Mr, indicative of rat β1 integrins. Specific staining of β1 integrin-like immunoreactivity was found in the vascular structures of the brain, including microvessels, the ventricular ependymal cells, and pia mater. The pineal gland stained densely, and diffuse staining was present throughout the gray matter of the brain. This diffuse staining had a patterned appearance in certain structures, such as the apical dendritic field of CA1 in hippocampus, and occasional labeling of astrocytes, verified by labeling with GFAP on adjacent sections, was noted.
UR - http://www.scopus.com/inward/record.url?scp=0027454036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027454036&partnerID=8YFLogxK
U2 - 10.1006/exnr.1993.1125
DO - 10.1006/exnr.1993.1125
M3 - Article
C2 - 7691647
AN - SCOPUS:0027454036
SN - 0014-4886
VL - 122
SP - 253
EP - 259
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -