Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals

P. M. Frossard, A. M. Bokhari, Y. I. Elshahat, G. G. Lestringant, A. M. John, S. H. Hill, A. M. Abdulle, E. N. Obineche

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention, ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28% of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.

Original languageEnglish (US)
Pages (from-to)713-719
Number of pages7
JournalSaudi Medical Journal
Volume19
Issue number6
StatePublished - 1998

Keywords

  • Angiotensin-converting enzyme
  • Cardiovascular diseases
  • Genetics
  • Hypertension
  • Myocardial infarction
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)

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