Animal models of headache: From bedside to bench and back to bedside

Anna P. Andreou, Oliver Summ, Annabelle R. Charbit, Marcela Romero-Reyes, Peter J. Goadsby

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent years bench-based studies have greatly enhanced our understanding of headache pathophysiology, while facilitating the development of new headache medicines. At present, established animal models of headache utilize activation of pain-producing cranial structures, which for a complex syndrome, such as migraine, leaves many dimensions of the syndrome unstudied. The focus on modeling the central nociceptive mechanisms and the complexity of sensory phenomena that accompany migraine may offer new approaches for the development of new therapeutics. Given the complexity of the primary headaches, multiple approaches and techniques need to be employed. As an example, recently a model for trigeminal autonomic cephalalgias has been tested successfully, while by contrast, a satisfactory model of tension-type headache has been elusive. Moreover, although useful in many regards, migraine models are yet to provide a more complete picture of the disorder.

Original languageEnglish (US)
Pages (from-to)389-411
Number of pages23
JournalExpert Review of Neurotherapeutics
Volume10
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Cortical-spreading depression
  • Migraine
  • Neurogenic vasodilation
  • Primary headaches
  • Trigeminocervical complex
  • Trigeminovascular system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

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