Anomalous sensitivity enhancement of nano-graphitic electrochemical micro-sensors with reducing the operating voltage

Edoardo Cuniberto, Abdullah Alharbi, Zhujun Huang, Ting Wu, Roozbeh Kiani, Davood Shahrjerdi

Research output: Contribution to journalArticlepeer-review

Abstract

Microscopic interactions between electrochemical sensors and biomolecules critically influence the sensitivity. Here, we report an unexpected dependence of the sensitivity on the upper potential limit (UPL) in voltammetry experiments. In particular, we find that the sensitivity of substrate-supported nano-graphitic micro-sensors in response to dopamine increases almost linearly with the inverse of UPL in voltammetry experiments with rapid potential sweeps. Our experiments and multi-physics simulations reveal that the main cause behind this phenomenon is the UPL-induced electrostatic force that influences the steady-state number of dopamine molecules on the sensor surface. Our findings illustrate a new strategy for enhancing the performance of planar electrochemical micro-sensors.

Original languageEnglish (US)
Article number112966
JournalBiosensors and Bioelectronics
Volume177
DOIs
StatePublished - Apr 1 2021

Keywords

  • Electrochemical sensor
  • Graphitic carbon
  • Sensitivity
  • Voltammetry sensing

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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