TY - JOUR
T1 - Anthropometric risk factors for cancers of the biliary tract in the biliary tract cancers pooling project
AU - Jackson, Sarah S.
AU - Van Dyke, Alison L.
AU - Zhu, Bin
AU - Pfeiffer, Ruth M.
AU - Petrick, Jessica L.
AU - Adami, Hans Olov
AU - Albanes, Demetrius
AU - Andreotti, Gabriella
AU - Beane Freeman, Laura E.
AU - De Gonzalez, Amy Berrington
AU - Buring, Julie E.
AU - Chan, Andrew T.
AU - Chen, Yu
AU - Fraser, Gary E.
AU - Freedman, Neal D.
AU - Gao, Yu Tang
AU - Gapstur, Susan M.
AU - Michael Gaziano, J.
AU - Giles, Graham G.
AU - Grant, Eric J.
AU - Grodstein, Francine
AU - Hartge, Patricia
AU - Jenab, Mazda
AU - Kitahara, Cari M.
AU - Knutsen, Synnove F.
AU - Koh, Woon Puay
AU - Larsson, Susanna C.
AU - Lee, I. Min
AU - Liao, Linda M.
AU - Luo, Juhua
AU - McGee, Emma E.
AU - Milne, Roger L.
AU - Monroe, Kristine R.
AU - Neuhouser, Marian L.
AU - O'Brien, Katie M.
AU - Peters, Ulrike
AU - Poynter, Jenny N.
AU - Purdue, Mark P.
AU - Robien, Kim
AU - Sandler, Dale P.
AU - Sawada, Norie
AU - Schairer, Catherine
AU - Sesso, Howard D.
AU - Simon, Tracey G.
AU - Sinha, Rashmi
AU - Stolzenberg-Solomon, Rachael Z.
AU - Tsugane, Shoichiro
AU - Wang, Renwei
AU - Weiderpass, Elisabete
AU - Weinstein, Stephanie J.
AU - White, Emily
AU - Wolk, Alicja
AU - Yuan, Jian Min
AU - Zeleniuch-Jacquotte, Anne
AU - Zhang, Xuehong
AU - McGlynn, Katherine A.
AU - Campbell, Peter T.
AU - Koshiol, Jill
N1 - Publisher Copyright:
© 2019 American Association for Cancer Research.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m2 increase in BMI, there were risk increases for GBC (HR ¼ 1.27; 95% CI, 1.19-1.36), IHBDC (HR ¼ 1.32; 95% CI, 1.21-1.45), and EHBDC (HR ¼ 1.13; 95% CI, 1.03-1.23), but not AVC (HR ¼ 0.99; 95% CI, 0.88-1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.
AB - Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m2 increase in BMI, there were risk increases for GBC (HR ¼ 1.27; 95% CI, 1.19-1.36), IHBDC (HR ¼ 1.32; 95% CI, 1.21-1.45), and EHBDC (HR ¼ 1.13; 95% CI, 1.03-1.23), but not AVC (HR ¼ 0.99; 95% CI, 0.88-1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.
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U2 - 10.1158/0008-5472.CAN-19-0459
DO - 10.1158/0008-5472.CAN-19-0459
M3 - Article
C2 - 31113819
AN - SCOPUS:85070094941
SN - 0008-5472
VL - 79
SP - 3973
EP - 3982
JO - Cancer Research
JF - Cancer Research
IS - 15
ER -