Anthropometry and head and neck cancer: A pooled analysis of cohort data

Mia M. Gaudet; Cari M. Kitahara; Christina C. Newton; Leslie Bernstein; Peggy Reynolds; Elisabete Weiderpass; Aimée R. Kreimer; Gong Yang; Hans Olov Adami; Michael C. Alavanja; Laura E. Beane Freeman; Heiner Boeing; Julie Buring; Anil Chaturvedi; Yu Chen; Aimee A. D'Aloisio; Michal Freedman; Yu Tang Gao; J. Michael Gaziano; Graham G. Giles; Niclas Håkansson; Wen Yi Huang; I. Min Lee; Martha S. Linet; Robert J. MacInnis; Yikyung Park; Anna Prizment; Mark P. Purdue; Elio Riboli; Kim Robien; Dale P. Sandler; Catherine Schairer; Howard D. Sesso; Xiao Ou Shu; Emily White; Alicja Wolk; Yong Bing Xiang; Anne Zelenuich-Jacquotte; Wei Zheng; Alpa V. Patel; Patricia Hartge; Amy Berrington De González; Susan M. Gapstur

doi:10.1093/ije/dyv059

Anthropometry and head and neck cancer: A pooled analysis of cohort data

Mia M. Gaudet, Cari M. Kitahara, Christina C. Newton, Leslie Bernstein, Peggy Reynolds, Elisabete Weiderpass, Aimée R. Kreimer, Gong Yang, Hans Olov Adami, Michael C. Alavanja, Laura E. Beane Freeman, Heiner Boeing, Julie Buring, Anil Chaturvedi, Yu Chen, Aimee A. D'Aloisio, Michal Freedman, Yu Tang Gao, J. Michael Gaziano, Graham G. GilesNiclas Håkansson, Wen Yi Huang, I. Min Lee, Martha S. Linet, Robert J. MacInnis, Yikyung Park, Anna Prizment, Mark P. Purdue, Elio Riboli, Kim Robien, Dale P. Sandler, Catherine Schairer, Howard D. Sesso, Xiao Ou Shu, Emily White, Alicja Wolk, Yong Bing Xiang, Anne Zelenuich-Jacquotte, Wei Zheng, Alpa V. Patel, Patricia Hartge, Amy Berrington De González, Susan M. Gapstur

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m²: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m²: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m²: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

Original language	English (US)
Pages (from-to)	673-681
Number of pages	9
Journal	International Journal of Epidemiology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1093/ije/dyv059
State	Published - May 27 2015

Keywords

Head and neck neoplasms
Obesity
Smoking
Waist circumference
Waist-hip ratio

ASJC Scopus subject areas

Epidemiology

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10.1093/ije/dyv059

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Gaudet, M. M., Kitahara, C. M., Newton, C. C., Bernstein, L., Reynolds, P., Weiderpass, E., Kreimer, A. R., Yang, G., Adami, H. O., Alavanja, M. C., Beane Freeman, L. E., Boeing, H., Buring, J., Chaturvedi, A., Chen, Y., D'Aloisio, A. A., Freedman, M., Gao, Y. T., Gaziano, J. M., ... Gapstur, S. M. (2015). Anthropometry and head and neck cancer: A pooled analysis of cohort data. International Journal of Epidemiology, 44(2), 673-681. https://doi.org/10.1093/ije/dyv059

Gaudet, MM, Kitahara, CM, Newton, CC, Bernstein, L, Reynolds, P, Weiderpass, E, Kreimer, AR, Yang, G, Adami, HO, Alavanja, MC, Beane Freeman, LE, Boeing, H, Buring, J, Chaturvedi, A, Chen, Y, D'Aloisio, AA, Freedman, M, Gao, YT, Gaziano, JM, Giles, GG, Håkansson, N, Huang, WY, Lee, IM, Linet, MS, MacInnis, RJ, Park, Y, Prizment, A, Purdue, MP, Riboli, E, Robien, K, Sandler, DP, Schairer, C, Sesso, HD, Shu, XO, White, E, Wolk, A, Xiang, YB, Zelenuich-Jacquotte, A, Zheng, W, Patel, AV, Hartge, P, De González, AB & Gapstur, SM 2015, 'Anthropometry and head and neck cancer: A pooled analysis of cohort data', International Journal of Epidemiology, vol. 44, no. 2, pp. 673-681. https://doi.org/10.1093/ije/dyv059

@article{a5442977fed640528dfac66175508666,

title = "Anthropometry and head and neck cancer: A pooled analysis of cohort data",

abstract = "Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.",

keywords = "Head and neck neoplasms, Obesity, Smoking, Waist circumference, Waist-hip ratio",

author = "Gaudet, {Mia M.} and Kitahara, {Cari M.} and Newton, {Christina C.} and Leslie Bernstein and Peggy Reynolds and Elisabete Weiderpass and Kreimer, {Aim{\'e}e R.} and Gong Yang and Adami, {Hans Olov} and Alavanja, {Michael C.} and {Beane Freeman}, {Laura E.} and Heiner Boeing and Julie Buring and Anil Chaturvedi and Yu Chen and D'Aloisio, {Aimee A.} and Michal Freedman and Gao, {Yu Tang} and Gaziano, {J. Michael} and Giles, {Graham G.} and Niclas H{\aa}kansson and Huang, {Wen Yi} and Lee, {I. Min} and Linet, {Martha S.} and MacInnis, {Robert J.} and Yikyung Park and Anna Prizment and Purdue, {Mark P.} and Elio Riboli and Kim Robien and Sandler, {Dale P.} and Catherine Schairer and Sesso, {Howard D.} and Shu, {Xiao Ou} and Emily White and Alicja Wolk and Xiang, {Yong Bing} and Anne Zelenuich-Jacquotte and Wei Zheng and Patel, {Alpa V.} and Patricia Hartge and {De Gonz{\'a}lez}, {Amy Berrington} and Gapstur, {Susan M.}",

year = "2015",

month = may,

day = "27",

doi = "10.1093/ije/dyv059",

language = "English (US)",

volume = "44",

pages = "673--681",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Anthropometry and head and neck cancer

T2 - A pooled analysis of cohort data

AU - Gaudet, Mia M.

AU - Kitahara, Cari M.

AU - Newton, Christina C.

AU - Bernstein, Leslie

AU - Reynolds, Peggy

AU - Weiderpass, Elisabete

AU - Kreimer, Aimée R.

AU - Yang, Gong

AU - Adami, Hans Olov

AU - Alavanja, Michael C.

AU - Beane Freeman, Laura E.

AU - Boeing, Heiner

AU - Buring, Julie

AU - Chaturvedi, Anil

AU - Chen, Yu

AU - D'Aloisio, Aimee A.

AU - Freedman, Michal

AU - Gao, Yu Tang

AU - Gaziano, J. Michael

AU - Giles, Graham G.

AU - Håkansson, Niclas

AU - Huang, Wen Yi

AU - Lee, I. Min

AU - Linet, Martha S.

AU - MacInnis, Robert J.

AU - Park, Yikyung

AU - Prizment, Anna

AU - Purdue, Mark P.

AU - Riboli, Elio

AU - Robien, Kim

AU - Sandler, Dale P.

AU - Schairer, Catherine

AU - Sesso, Howard D.

AU - Shu, Xiao Ou

AU - White, Emily

AU - Wolk, Alicja

AU - Xiang, Yong Bing

AU - Zelenuich-Jacquotte, Anne

AU - Zheng, Wei

AU - Patel, Alpa V.

AU - Hartge, Patricia

AU - De González, Amy Berrington

AU - Gapstur, Susan M.

PY - 2015/5/27

Y1 - 2015/5/27

N2 - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

AB - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

KW - Head and neck neoplasms

KW - Obesity

KW - Smoking

KW - Waist circumference

KW - Waist-hip ratio

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DO - 10.1093/ije/dyv059

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SN - 0300-5771

VL - 44

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EP - 681

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

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ER -

Anthropometry and head and neck cancer: A pooled analysis of cohort data

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