Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A. Bokulich; Jennifer Chung; Thomas Battaglia; Nora Henderson; Melanie Jay; Huilin Li; Arnon D. Lieber; Fen Wu; Guillermo I. Perez-Perez; Yu Chen; William Schweizer; Xuhui Zheng; Monica Contreras; Maria Gloria Dominguez-Bello; Martin J. Blaser

doi:10.1126/scitranslmed.aad7121

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A. Bokulich, Jennifer Chung, Thomas Battaglia, Nora Henderson, Melanie Jay, Huilin Li, Arnon D. Lieber, Fen Wu, Guillermo I. Perez-Perez, Yu Chen, William Schweizer, Xuhui Zheng, Monica Contreras, Maria Gloria Dominguez-Bello, Martin J. Blaser

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

Original language	English (US)
Article number	343ra82
Journal	Science Translational Medicine
Volume	8
Issue number	343
DOIs	https://doi.org/10.1126/scitranslmed.aad7121
State	Published - Jun 15 2016

ASJC Scopus subject areas

General Medicine

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Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., Lieber, A. D., Wu, F., Perez-Perez, G. I., Chen, Y., Schweizer, W., Zheng, X., Contreras, M., Dominguez-Bello, M. G., & Blaser, M. J. (2016). Antibiotics, birth mode, and diet shape microbiome maturation during early life. Science Translational Medicine, 8(343), Article 343ra82. https://doi.org/10.1126/scitranslmed.aad7121

Bokulich, NA, Chung, J, Battaglia, T, Henderson, N, Jay, M, Li, H, Lieber, AD, Wu, F, Perez-Perez, GI, Chen, Y, Schweizer, W, Zheng, X, Contreras, M, Dominguez-Bello, MG & Blaser, MJ 2016, 'Antibiotics, birth mode, and diet shape microbiome maturation during early life', Science Translational Medicine, vol. 8, no. 343, 343ra82. https://doi.org/10.1126/scitranslmed.aad7121

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abstract = "Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.",

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AU - Lieber, Arnon D.

AU - Wu, Fen

AU - Perez-Perez, Guillermo I.

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AU - Schweizer, William

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AU - Dominguez-Bello, Maria Gloria

AU - Blaser, Martin J.

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Antibiotics, birth mode, and diet shape microbiome maturation during early life

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