TY - JOUR
T1 - Antibiotics, birth mode, and diet shape microbiome maturation during early life
AU - Bokulich, Nicholas A.
AU - Chung, Jennifer
AU - Battaglia, Thomas
AU - Henderson, Nora
AU - Jay, Melanie
AU - Li, Huilin
AU - Lieber, Arnon D.
AU - Wu, Fen
AU - Perez-Perez, Guillermo I.
AU - Chen, Yu
AU - Schweizer, William
AU - Zheng, Xuhui
AU - Contreras, Monica
AU - Dominguez-Bello, Maria Gloria
AU - Blaser, Martin J.
N1 - Funding Information:
This study was supported by grant R01 DK090989 from NIH, Public Health Service Institutional Research Training Award T32 AI007180, the Diane Belfer Program for Human Microbial Ecology, the Daniel and Leslie ZiffFund, andthe C and D fund. N.A.B. is a co-founder of MicroTrek Inc., a company focused on microbial analysis for food, beverage, health, and other industries. MicroTrek was not involved in funding, design, or interpretation of this study. M.G.D.-B., together with NYU Langone Medical Center (LMC), has intellectual property related to the restoration of the microbiome of newborns, which has been licensed to Commense Inc. M.G.D.-B. and M.J.B. are co-founders and equity holders in Commense Inc., which is focused on the restoration of depleted microbiota in early life. Commense was not involved in the funding, design, or interpretation of this study. M.J.B. serves as a consultant to Johnson and Johnson, which funds unrelated studies in his laboratory at NYU LMC. The other authors declare that they have no competing interests. in QIITA database (https://qiita.microbio.me/) under study ID 10249.
Publisher Copyright:
© 2016, American Association for the Advancement of Science. All rights reserved.
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
AB - Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
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U2 - 10.1126/scitranslmed.aad7121
DO - 10.1126/scitranslmed.aad7121
M3 - Article
C2 - 27306664
AN - SCOPUS:84975068696
SN - 1946-6234
VL - 8
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 343
M1 - 343ra82
ER -