Antigen processing and presentation of vesicular stomatitis virus glycoprotein

Research output: Contribution to journalArticle

Abstract

Antigen processing and presentation is the complex series of steps involving numerous compartments of cells derived from multiple lineages. This collective process is central to the initiation of specific cellular immune responses. Internalization of foreign proteins or infectious agents, degradation of proteins to peptides, and transfer to 1a heterodimers which are then translocated to the cell surface, comprise the pathway. This can be blocked by drugs which interfere with compartment acidification (ammonium chloride, methylamine, chloroquine), protein synthesis (emetine), vesicle trafficking (brefeldin A), and microtubule metabolism (taxol, colchicine, nocadazole).

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalSeminars in Virology
Volume4
Issue number2
DOIs
StatePublished - 1993

Keywords

  • Antigen presentation
  • Antigen processing
  • Endosome
  • Ia biosynthesis

ASJC Scopus subject areas

  • Immunology
  • Virology

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