Antiviral activities in human saliva.

D. Malamud, W. R. Abrams, C. A. Barber, D. Weissman, M. Rehtanz, E. Golub

    Research output: Contribution to journalReview articlepeer-review


    In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.

    Original languageEnglish (US)
    Pages (from-to)34-37
    Number of pages4
    JournalAdvances in dental research
    Issue number1
    StatePublished - Apr 2011

    ASJC Scopus subject areas

    • General Medicine


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