TY - JOUR
T1 - Antiviral activities in human saliva.
AU - Malamud, D.
AU - Abrams, W. R.
AU - Barber, C. A.
AU - Weissman, D.
AU - Rehtanz, M.
AU - Golub, E.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.
AB - In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.
UR - http://www.scopus.com/inward/record.url?scp=79954601585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954601585&partnerID=8YFLogxK
U2 - 10.1177/0022034511399282
DO - 10.1177/0022034511399282
M3 - Review article
C2 - 21441478
AN - SCOPUS:79954601585
SN - 0895-9374
VL - 23
SP - 34
EP - 37
JO - Advances in dental research
JF - Advances in dental research
IS - 1
ER -