Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray

William J. Apfeldorf; Lisa A. Spielman; Marylene Cloitre; Leora Heckelman; M. Katherine Shear

doi:10.1002/1520-6394(2000)12:2<99::aid-da6>3.0.co;2-q

Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray

William J. Apfeldorf, Lisa A. Spielman, Marylene Cloitre, Leora Heckelman, M. Katherine Shear

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Abstract

Corticotropin-releasing hormone (CRH) is anxiogenic when microinjected into the dorsal periaqueductal gray (DPAG). Microinjection of alpha-helical-CRH9-41 (0.5 μg), a CRH receptor antagonist, bowever, failed to change anxiety levels. The objective of this study was to verify if this compound has any effect in the anxiogenic behavior of rats submitted to 4 hr of restraint stress 24 hr before the test in an elevated plus maze. Results showed that stressed rats had a decreased exploration of open arms without changing the number of enclosed arm entries. The stress effect was reversed by intra-DPAG injection of alpha-helical-CRH9-41 (0.5 μg). These results suggest that the anxiogenic behavior of rats previously stressed by forced immobilization might involve facilitation of CRH-mediated neurotransmission in the DPAG. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	99-101
Number of pages	3
Journal	Depression and Anxiety
Volume	12
Issue number	2
DOIs	https://doi.org/10.1002/1520-6394(2000)12:2<99::aid-da6>3.0.co;2-q
State	Published - 2000

Keywords

Anxiety
Corticotropin releasing hormone
CRH
CRH antagonist
Dorsal periaqueductal gray
Elevated plus-maze

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1002/1520-6394(2000)12:2<99::aid-da6>3.0.co;2-q

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title = "Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray",

abstract = "Corticotropin-releasing hormone (CRH) is anxiogenic when microinjected into the dorsal periaqueductal gray (DPAG). Microinjection of alpha-helical-CRH9-41 (0.5 μg), a CRH receptor antagonist, bowever, failed to change anxiety levels. The objective of this study was to verify if this compound has any effect in the anxiogenic behavior of rats submitted to 4 hr of restraint stress 24 hr before the test in an elevated plus maze. Results showed that stressed rats had a decreased exploration of open arms without changing the number of enclosed arm entries. The stress effect was reversed by intra-DPAG injection of alpha-helical-CRH9-41 (0.5 μg). These results suggest that the anxiogenic behavior of rats previously stressed by forced immobilization might involve facilitation of CRH-mediated neurotransmission in the DPAG. (C) 2000 Wiley-Liss, Inc.",

keywords = "Anxiety, Corticotropin releasing hormone, CRH, CRH antagonist, Dorsal periaqueductal gray, Elevated plus-maze",

author = "Apfeldorf, {William J.} and Spielman, {Lisa A.} and Marylene Cloitre and Leora Heckelman and {Katherine Shear}, M.",

year = "2000",

doi = "10.1002/1520-6394(2000)12:2<99::aid-da6>3.0.co;2-q",

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T1 - Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray

AU - Apfeldorf, William J.

AU - Spielman, Lisa A.

AU - Cloitre, Marylene

AU - Heckelman, Leora

AU - Katherine Shear, M.

PY - 2000

Y1 - 2000

N2 - Corticotropin-releasing hormone (CRH) is anxiogenic when microinjected into the dorsal periaqueductal gray (DPAG). Microinjection of alpha-helical-CRH9-41 (0.5 μg), a CRH receptor antagonist, bowever, failed to change anxiety levels. The objective of this study was to verify if this compound has any effect in the anxiogenic behavior of rats submitted to 4 hr of restraint stress 24 hr before the test in an elevated plus maze. Results showed that stressed rats had a decreased exploration of open arms without changing the number of enclosed arm entries. The stress effect was reversed by intra-DPAG injection of alpha-helical-CRH9-41 (0.5 μg). These results suggest that the anxiogenic behavior of rats previously stressed by forced immobilization might involve facilitation of CRH-mediated neurotransmission in the DPAG. (C) 2000 Wiley-Liss, Inc.

AB - Corticotropin-releasing hormone (CRH) is anxiogenic when microinjected into the dorsal periaqueductal gray (DPAG). Microinjection of alpha-helical-CRH9-41 (0.5 μg), a CRH receptor antagonist, bowever, failed to change anxiety levels. The objective of this study was to verify if this compound has any effect in the anxiogenic behavior of rats submitted to 4 hr of restraint stress 24 hr before the test in an elevated plus maze. Results showed that stressed rats had a decreased exploration of open arms without changing the number of enclosed arm entries. The stress effect was reversed by intra-DPAG injection of alpha-helical-CRH9-41 (0.5 μg). These results suggest that the anxiogenic behavior of rats previously stressed by forced immobilization might involve facilitation of CRH-mediated neurotransmission in the DPAG. (C) 2000 Wiley-Liss, Inc.

KW - Anxiety

KW - Corticotropin releasing hormone

KW - CRH

KW - CRH antagonist

KW - Dorsal periaqueductal gray

KW - Elevated plus-maze

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Anxiolytic effect of a CRH receptor antagonist in the dorsal periaqueductal gray

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Keywords

ASJC Scopus subject areas

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