APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

Aykut Aytulun, Andrés Cruz-Herranz, Orhan Aktas, Laura J. Balcer, Lisanne Balk, Piero Barboni, Augusto Azuara Blanco, Peter A. Calabresi, Fiona Costello, Bernardo Sanchez-Dalmau, Delia Cabrera Debuc, Nicolas Feltgen, Robert P. Finger, Jette Lautrup Frederiksen, Elliot Frohman, Teresa Frohman, David Garway-Heath, Iñigo Gabilondo, Jennifer S. Graves, Ari J. GreenHans Peter Hartung, Joachim Havla, Frank G. Holz, Jaime Imitola, Rachel Kenney, Alexander Klistorner, Benjamin Knier, Thomas Korn, Scott Kolbe, Julia Krämer, Wolf A. Lagrèze, Letizia Leocani, Oliver Maier, Elena H. Martínez-Lapiscina, Sven Meuth, Olivier Outteryck, Friedemann Paul, Axel Petzold, Gorm Pihl-Jensen, Jana Lizrova Preiningerova, Gema Rebolleda, Marius Ringelstein, Shiv Saidha, Sven Schippling, Joel S. Schuman, Robert C. Sergott, Ahmed Toosy, Pablo Villoslada, Sebastian Wolf, E. Ann Yeh, Patrick Yu-Wai-Man, Hanna G. Zimmermann, Alexander U. Brandt, Philipp Albrecht

Research output: Contribution to journalArticlepeer-review


ObjectiveTo update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations.MethodsTo identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative"and "optical coherence tomography"from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial APOSTEL recommendations via online surveys following the principle of a modified Delphi method. The results were evaluated and discussed by a panel of experts and changes to the initial recommendations were proposed. A final survey was recirculated among the corresponding authors to obtain a majority vote on the proposed changes.ResultsA total of 116 authors participated in the surveys, resulting in 15 suggestions, of which 12 were finally accepted and incorporated into an updated 9-point checklist. We harmonized the nomenclature of the outer retinal layers, added the exact area of measurement to the description of volume scans, and suggested reporting device-specific features. We advised to address potential bias in manual segmentation or manual correction of segmentation errors. References to specific reporting guidelines and room light conditions were removed. The participants' consensus with the recommendations increased from 80% for the previous APOSTEL version to greater than 90%.ConclusionsThe modified Delphi method resulted in an expert-led guideline (evidence Class III; Grading of Recommendations, Assessment, Development and Evaluations [GRADE] criteria) concerning study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition analysis, nomenclature and abbreviations, and statistical approach. It will be essential to update these recommendations to new research and practices regularly.

Original languageEnglish (US)
Pages (from-to)68-79
Number of pages12
Issue number2
StatePublished - Jul 13 2021

ASJC Scopus subject areas

  • Clinical Neurology


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