Applications of 3D bioprinted-induced pluripotent stem cells in healthcare

Soja Saghar Soman, Sanjairaj Vijayavenkataraman

Research output: Contribution to journalReview articlepeer-review

Abstract

Induced pluripotent stem cell (iPSC) technology and advancements in three-dimensional (3D) bioprinting technology enable scientists to reprogram somatic cells to iPSCs and 3D print iPSC-derived organ constructs with native tissue architecture and function. iPSCs and iPSC-derived cells suspended in hydrogels (bioinks) allow to print tissues and organs for downstream medical applications. The bioprinted human tissues and organs are extremely valuable in regenerative medicine as bioprinting of autologous iPSC-derived organs eliminates the risk of immune rejection with organ transplants. Disease modeling and drug screening in bioprinted human tissues will give more precise information on disease mechanisms, drug efficacy, and drug toxicity than experimenting on animal models. Bioprinted iPSC-derived cancer tissues will aid in the study of early cancer development and precision oncology to discover patient-specific drugs. In this review, we present a brief summary of the combined use of two powerful technologies, iPSC technology, and 3D bioprinting in health-care applications.

Original languageEnglish (US)
Article number280
JournalInternational Journal of Bioprinting
Volume6
Issue number4
DOIs
StatePublished - 2020

Keywords

  • Cancer iPSCs
  • Disease modeling
  • Drug screening
  • Induced pluripotent stem cells
  • Regenerative medicine
  • Three-dimensional bioprinting

ASJC Scopus subject areas

  • Biotechnology
  • Materials Science (miscellaneous)
  • Industrial and Manufacturing Engineering

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