Arginylation of β-actin regulates actin cytoskeleton and cell motility

Marina Karakozova, Marina Kozak, Catherine C L Wong, Aaron O. Bailey, John R. Yates, Alexander Mogilner, Henry Zebroski, Anna Kashina

Research output: Contribution to journalArticlepeer-review

Abstract

Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that β-actin was arginylated in vivo to regulate actin filament properties, β-actin localization, and lamella formation in motile cells. Arginylation of β-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalScience
Volume313
Issue number5784
DOIs
StatePublished - Jul 14 2006

ASJC Scopus subject areas

  • General

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