TY - JOUR
T1 - Arsenic exposure and impaired lung function findings from a large population-based prospective cohort study
AU - Parvez, Faruque
AU - Chen, Yu
AU - Yunus, Mahbub
AU - Olopade, Mahbub
AU - Segers, S.
AU - Slavkovich, Vesna
AU - Argos, Maria
AU - Hasan, Rabiul
AU - Ahmed, Alauddin
AU - Islam, Tariqul
AU - Akter, Mahmud M.
AU - Graziano, Joseph H.
AU - Ahsan, Habibul
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Rationale: Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. Objectives: To determine the deleterious effects on lung function that exist among individuals exposed to a high dose of arsenic. Methods: In 950 individuals who presented with any respiratory symptom among a population-based cohort of 20,033 adults, we evaluated the association between arsenic exposure, measured by well water and urinary arsenic concentrations measured at baseline, and post- bronchodilatoradministered pulmonary function assessed during follow-up. Measurements andMainResults: For everyoneSDincrease inbaseline water arsenic exposure, we observed a lower level of FEV1 (246.5 ml; P , 0.0005) and FVC (253.1 ml; P , 0.01) in regression models adjusted for age, sex, bodymass index, smoking, socioeconomic status, betelnut use, and arsenical skin lesions status. Similar inverse relationships were observed between baseline urinary arsenic and FEV1 (248.3 ml; P , 0.005) and FVC (255.2 ml; P , 0.01) in adjustedmodels. Our analyses also demonstrated a dose-related decrease in lung function with increasing levels of baseline water and urinary arsenic. This associationremainedsignificant innever-smokersandindividuals without skin lesions, and was stronger inmale smokers. Among male smokers and individuals with skin lesions, every one SD increase in water arsenic was related to a significant reduction of FEV1 (274.4ml, P , 0.01; and 2116.1 ml, P , 0.05) and FVC (272.8 ml, P = 0.02; and 2146.9 ml, P = 0.004), respectively. Conclusions: This large population-based studyconfirms that arsenic exposure is associated with impaired lung function and the deleterious effect is evident at low- to moderate-dose range.
AB - Rationale: Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. Objectives: To determine the deleterious effects on lung function that exist among individuals exposed to a high dose of arsenic. Methods: In 950 individuals who presented with any respiratory symptom among a population-based cohort of 20,033 adults, we evaluated the association between arsenic exposure, measured by well water and urinary arsenic concentrations measured at baseline, and post- bronchodilatoradministered pulmonary function assessed during follow-up. Measurements andMainResults: For everyoneSDincrease inbaseline water arsenic exposure, we observed a lower level of FEV1 (246.5 ml; P , 0.0005) and FVC (253.1 ml; P , 0.01) in regression models adjusted for age, sex, bodymass index, smoking, socioeconomic status, betelnut use, and arsenical skin lesions status. Similar inverse relationships were observed between baseline urinary arsenic and FEV1 (248.3 ml; P , 0.005) and FVC (255.2 ml; P , 0.01) in adjustedmodels. Our analyses also demonstrated a dose-related decrease in lung function with increasing levels of baseline water and urinary arsenic. This associationremainedsignificant innever-smokersandindividuals without skin lesions, and was stronger inmale smokers. Among male smokers and individuals with skin lesions, every one SD increase in water arsenic was related to a significant reduction of FEV1 (274.4ml, P , 0.01; and 2116.1 ml, P , 0.05) and FVC (272.8 ml, P = 0.02; and 2146.9 ml, P = 0.004), respectively. Conclusions: This large population-based studyconfirms that arsenic exposure is associated with impaired lung function and the deleterious effect is evident at low- to moderate-dose range.
KW - Arsenic exposure
KW - Bangladesh
KW - Lung function
UR - http://www.scopus.com/inward/record.url?scp=84886266136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886266136&partnerID=8YFLogxK
U2 - 10.1164/rccm.201212-2282OC
DO - 10.1164/rccm.201212-2282OC
M3 - Article
C2 - 23848239
AN - SCOPUS:84886266136
SN - 1073-449X
VL - 188
SP - 813
EP - 819
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 7
ER -