TY - JOUR
T1 - Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh
T2 - Baseline results from the health effects of arsenic longitudinal study
AU - Ahsan, Habibul
AU - Chen, Yu
AU - Parvez, Faruque
AU - Zablotska, Lydia
AU - Argos, Maria
AU - Hussain, Iftikhar
AU - Momotaj, Hassina
AU - Levy, Diane
AU - Cheng, Zhongqi
AU - Slavkovich, Vesna
AU - Van Geen, Alexander
AU - Howe, Geoffrey R.
AU - Graziano, Joseph H.
N1 - Funding Information:
This research was supported by US National Institutes of Health grants (Bethesda, Maryland) P42 ES10349, P30 ES09089, and R01 CA102484. The authors thank the dedicated project staff and field workers in Bangladesh, without whom this work would not have been possible. Conflict of interest: none declared.
PY - 2006/6
Y1 - 2006/6
N2 - Millions of persons around the world are exposed to low doses of arsenic through drinking water. However, estimates of health effects associated with low-dose arsenic exposure have been extrapolated from high-dose studies. In Bangladesh, many persons have been exposed to a wide range of doses of arsenic from drinking water over a significant period of time. The authors evaluated dose-response relations between arsenic exposure from drinking water and premalignant skin lesions by using baseline data on 11,746 participants recruited in 2000-2002 for the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh. Several measures of arsenic exposure were estimated for each participant based on well-water arsenic concentration and usage pattern of the wells and on urinary arsenic concentration. In different regression models, consistent dose-response effects were observed for all arsenic exposure measures. Compared with drinking water containing <8.1 μg/liter of arsenic, drinking water containing 8.1-40.0, 40.1-91.0, 91.1-175.0, and 175.1-864.0 μg/liter of arsenic was associated with adjusted prevalence odds ratios of skin lesions of 1.91 (95% confidence interval (CI): 1.26, 2.89), 3.03 (95% CI: 2.05, 4.50), 3.71 (95% CI: 2.53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions.
AB - Millions of persons around the world are exposed to low doses of arsenic through drinking water. However, estimates of health effects associated with low-dose arsenic exposure have been extrapolated from high-dose studies. In Bangladesh, many persons have been exposed to a wide range of doses of arsenic from drinking water over a significant period of time. The authors evaluated dose-response relations between arsenic exposure from drinking water and premalignant skin lesions by using baseline data on 11,746 participants recruited in 2000-2002 for the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh. Several measures of arsenic exposure were estimated for each participant based on well-water arsenic concentration and usage pattern of the wells and on urinary arsenic concentration. In different regression models, consistent dose-response effects were observed for all arsenic exposure measures. Compared with drinking water containing <8.1 μg/liter of arsenic, drinking water containing 8.1-40.0, 40.1-91.0, 91.1-175.0, and 175.1-864.0 μg/liter of arsenic was associated with adjusted prevalence odds ratios of skin lesions of 1.91 (95% confidence interval (CI): 1.26, 2.89), 3.03 (95% CI: 2.05, 4.50), 3.71 (95% CI: 2.53, 5.44), and 5.39 (95% CI: 3.69, 7.86), respectively. The effect seemed to be influenced by gender, age, and body mass index. These findings provide information that should be considered in future research and policy decisions.
KW - Arsenic
KW - Bangladesh
KW - Cross-sectional studies
KW - Environmental exposure
KW - Keratosis
KW - Melanosis
KW - Risk
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U2 - 10.1093/aje/kwj154
DO - 10.1093/aje/kwj154
M3 - Article
C2 - 16624965
AN - SCOPUS:33745600121
SN - 0002-9262
VL - 163
SP - 1138
EP - 1148
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 12
ER -