Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: A population-based, cross-sectional study

Yu Chen, Pam Factor-Litvak, Geoffrey R. Howe, Joseph H. Graziano, Paul Brandt-Rauf, Faruque Parvez, Alexander Van Geen, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

The authors performed a cross-sectional analysis to evaluate the association between arsenic exposure from drinking water and blood pressure using baseline data of 10,910 participants in the Health Effects of Arsenic Longitudinal Study in Bangladesh (October 2000-May 2002). A time-weighted well arsenic concentration (TWA) based on current and past use of drinking wells was derived. Odds ratios for high pulse pressure (≥55 mmHg) by increasing TWA quintiles (≤8, 8.1-40.8, 40.9-91.0, 91.1-176.0, and 176.1-864.0 μg/liter) were 1.00 (referent), 1.39 (95% confidence interval (CI): 1.14, 1.71), 1.21 (95% CI: 0.99, 1.49), 1.19 (95% CI: 0.97, 1.45), and 1.19 (95% CI: 0.97, 1.46). Among participants with a lower than average dietary intake level of B vitamins and folate, the odds ratios for high pulse pressure by increasing TWA quintiles were 1.00 (referent), 1.84 (95% CI: 1.07, 3.16), 1.89 (95% CI: 1.11, 3.20), 1.83 (95% CI: 1.09, 3.07), and 1.89 (95% CI: 1.12, 3.20). The odds ratios for systolic hypertension suggest a similar but weaker association. No apparent associations were observed between TWA and general or diastolic hypertension. These findings indicate that the effect of low-level arsenic exposure on blood pressure is nonlinear and may be more pronounced in persons with lower intake of nutrients related to arsenic metabolism and cardiovascular health. Future research is needed to evaluate the effect of low-level arsenic exposure on specific cardiovascular outcomes.

Original languageEnglish (US)
Pages (from-to)541-552
Number of pages12
JournalAmerican Journal of Epidemiology
Volume165
Issue number5
DOIs
StatePublished - Mar 2007

Keywords

  • Arsenic
  • Bangladesh
  • Blood pressure
  • Cross-sectional studies
  • Hypertension

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: A population-based, cross-sectional study'. Together they form a unique fingerprint.

  • Cite this