TY - JOUR
T1 - Arsenic species and selected metals in human urine
T2 - Validation of HPLC/ICPMS and ICPMS procedures for a long-term population-based epidemiological study
AU - Scheer, Jürgen
AU - Findenig, Silvia
AU - Goessler, Walter
AU - Francesconi, Kevin A.
AU - Howard, Barbara
AU - Umans, Jason G.
AU - Pollak, Jonathan
AU - Tellez-Plaza, Maria
AU - Silbergeld, Ellen K.
AU - Guallar, Eliseo
AU - Navas-Acien, Ana
PY - 2012/2
Y1 - 2012/2
N2 - Exposure to high inorganic arsenic concentrations in drinking water has been related to detrimental health effects, including cancers and possibly cardiovascular disease, in many epidemiological studies. Recent studies suggest that arsenic might elicit some of its toxic effects also at lower concentrations. The Strong Heart Study, a large epidemiological study of cardiovascular disease in American Indian communities, collected urine samples and performed medical examinations on 4549 participants over a 10 year period beginning in 1989. We used anion-exchange HPLC/ICPMS to determine concentrations of arsenic species (methylarsonate, dimethylarsinate and arsenate) in 5095 urine samples from the Strong Heart Study. We repeated the chromatography on a portion of the urine sample that had been oxidised, by addition of H 2O 2, to provide additional information on the presence of As(iii) species and thio-arsenicals, and by difference, of arsenobetaine and other non-retained cations. Total concentrations for As, Cd, Mo, Pb, Sb, Se, U, W, and Zn were also determined in the urine samples by ICPMS. The dataset will be used to evaluate the relationships between the concentrations of urinary arsenic species and selected metals with various cardiometabolic health endpoints. We present and discuss the analytical protocol put in place to produce this large and valuable dataset.
AB - Exposure to high inorganic arsenic concentrations in drinking water has been related to detrimental health effects, including cancers and possibly cardiovascular disease, in many epidemiological studies. Recent studies suggest that arsenic might elicit some of its toxic effects also at lower concentrations. The Strong Heart Study, a large epidemiological study of cardiovascular disease in American Indian communities, collected urine samples and performed medical examinations on 4549 participants over a 10 year period beginning in 1989. We used anion-exchange HPLC/ICPMS to determine concentrations of arsenic species (methylarsonate, dimethylarsinate and arsenate) in 5095 urine samples from the Strong Heart Study. We repeated the chromatography on a portion of the urine sample that had been oxidised, by addition of H 2O 2, to provide additional information on the presence of As(iii) species and thio-arsenicals, and by difference, of arsenobetaine and other non-retained cations. Total concentrations for As, Cd, Mo, Pb, Sb, Se, U, W, and Zn were also determined in the urine samples by ICPMS. The dataset will be used to evaluate the relationships between the concentrations of urinary arsenic species and selected metals with various cardiometabolic health endpoints. We present and discuss the analytical protocol put in place to produce this large and valuable dataset.
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U2 - 10.1039/c2ay05638k
DO - 10.1039/c2ay05638k
M3 - Article
AN - SCOPUS:84856846739
SN - 1759-9660
VL - 4
SP - 406
EP - 413
JO - Analytical Methods
JF - Analytical Methods
IS - 2
ER -