Art therapy for Parkinson's disease

Alberto Cucca, Alessandro Di Rocco, Ikuko Acosta, Mahya Beheshti, Marygrace Berberian, Hilary C. Bertisch, Amgad Droby, Tom Ettinger, Todd E. Hudson, Matilde Inglese, Yoon J. Jung, Daniella F. Mania, Angelo Quartarone, John Ross Rizzo, Kush Sharma, Andrew Feigin, Milton C. Biagioni, M. Felice Ghilardi

Research output: Contribution to journalArticlepeer-review


Objective: To explore the potential rehabilitative effect of art therapy and its underlying mechanisms in Parkinson's disease (PD). Methods: Observational study of eighteen patients with PD, followed in a prospective, open-label, exploratory trial. Before and after twenty sessions of art therapy, PD patients were assessed with the UPDRS, Pegboard Test, Timed Up and Go Test (TUG), Beck Depression Inventory (BDI), Modified Fatigue Impact Scale and PROMIS-Self-Efficacy, Montreal Cognitive Assessment, Rey-Osterrieth Complex Figure Test (RCFT), Benton Visual Recognition Test (BVRT), Navon Test, Visual Search, and Stop Signal Task. Eye movements were recorded during the BVRT. Resting-state functional MRI (rs-fMRI) was also performed to assess functional connectivity (FC) changes within the dorsal attention (DAN), executive control (ECN), fronto-occipital (FOC), salience (SAL), primary and secondary visual (V1, V2) brain networks. We also tested fourteen age-matched healthy controls at baseline. Results: At baseline, PD patients showed abnormal visual-cognitive functions and eye movements. Analyses of rs-fMRI showed increased functional connectivity within DAN and ECN in patients compared to controls. Following art therapy, performance improved on Navon test, eye tracking, and UPDRS scores. Rs-fMRI analysis revealed significantly increased FC levels in brain regions within V1 and V2 networks. Interpretation: Art therapy improves overall visual-cognitive skills and visual exploration strategies as well as general motor function in patients with PD. The changes in brain connectivity highlight a functional reorganization of visual networks.

Original languageEnglish (US)
Pages (from-to)148-154
Number of pages7
JournalParkinsonism and Related Disorders
StatePublished - Mar 2021


  • Art therapy
  • Eye tracking
  • Parkinson's disease
  • Rehabilitation
  • Rs-fMRI

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


Dive into the research topics of 'Art therapy for Parkinson's disease'. Together they form a unique fingerprint.

Cite this