TY - JOUR
T1 - Artificial receptors for biologically active molecules
AU - Hamilton, Andrew D.
AU - Pant, Nalin
AU - Muehldorf, Alexander
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Artificial receptors for two key classes of bio- logical molecules, nucleotides and peptides, have been prepared. The nucleotide receptors mimick nucleotide binding enzymes by employing a multi-point binding strategy within a flexible cavity. Complementary hydrogen bonding and hydrophobic groups have been linked within a macrocyclic ring to provide a series of thymine receptors. Binding has been studied by NMR and X-ray crystallographic methods which show that both components interact with the bound substrate. A series of potential peptide receptors based on the antibiotic, vancomycin, have also been prepared and their structural and functional similarities to the natural product have been studied.
AB - Artificial receptors for two key classes of bio- logical molecules, nucleotides and peptides, have been prepared. The nucleotide receptors mimick nucleotide binding enzymes by employing a multi-point binding strategy within a flexible cavity. Complementary hydrogen bonding and hydrophobic groups have been linked within a macrocyclic ring to provide a series of thymine receptors. Binding has been studied by NMR and X-ray crystallographic methods which show that both components interact with the bound substrate. A series of potential peptide receptors based on the antibiotic, vancomycin, have also been prepared and their structural and functional similarities to the natural product have been studied.
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U2 - 10.1351/pac198860040533
DO - 10.1351/pac198860040533
M3 - Article
AN - SCOPUS:0000603186
SN - 0033-4545
VL - 60
SP - 533
EP - 538
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
IS - 4
ER -