Artificial receptors for two key classes of bio- logical molecules, nucleotides and peptides, have been prepared. The nucleotide receptors mimick nucleotide binding enzymes by employing a multi-point binding strategy within a flexible cavity. Complementary hydrogen bonding and hydrophobic groups have been linked within a macrocyclic ring to provide a series of thymine receptors. Binding has been studied by NMR and X-ray crystallographic methods which show that both components interact with the bound substrate. A series of potential peptide receptors based on the antibiotic, vancomycin, have also been prepared and their structural and functional similarities to the natural product have been studied.
ASJC Scopus subject areas
- Chemical Engineering(all)