Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

Charlotte L. Sutherell; Sam Thompson; Richard T.W. Scott; Andrew D. Hamilton

doi:10.1039/c2cc34791a

Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

Charlotte L. Sutherell, Sam Thompson, Richard T.W. Scott, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

Original language	English (US)
Pages (from-to)	9834-9836
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	79
DOIs	https://doi.org/10.1039/c2cc34791a
State	Published - Sep 10 2012

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc34791a

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abstract = "We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.",

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Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

Abstract

ASJC Scopus subject areas

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