Low levels of ascorbic acid reversibly inhibit mouse brain and beef heart cyclic nucleotide phosphodiesterase activity in vitro. Inhibition is noncompetitive with a Ki = 10-4 M. Similar inhibition occurs with D-ascorbate but not with dehydroascorbate or metabisulfite. The kinetics of inhibition by ascorbic acid were similar for “high” and “low” Km cAMP phosphodiesterase and cGMP phosphodiesterase activity.
|Original language||English (US)|
|Number of pages||3|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 1980|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)