Ascorbic Acid Inhibition of Cyclic Nucleotide Phosphodiesterase Activity

Daniel Malamud, Yale Kroll

    Research output: Contribution to journalArticlepeer-review


    Low levels of ascorbic acid reversibly inhibit mouse brain and beef heart cyclic nucleotide phosphodiesterase activity in vitro. Inhibition is noncompetitive with a Ki = 10-4 M. Similar inhibition occurs with D-ascorbate but not with dehydroascorbate or metabisulfite. The kinetics of inhibition by ascorbic acid were similar for “high” and “low” Km cAMP phosphodiesterase and cGMP phosphodiesterase activity.

    Original languageEnglish (US)
    Pages (from-to)534-536
    Number of pages3
    JournalProceedings of the Society for Experimental Biology and Medicine
    Issue number4
    StatePublished - Sep 1980

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology


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