Ascorbic Acid Inhibition of Cyclic Nucleotide Phosphodiesterase Activity

Daniel Malamud, Yale Kroll

Research output: Contribution to journalArticlepeer-review


Low levels of ascorbic acid reversibly inhibit mouse brain and beef heart cyclic nucleotide phosphodiesterase activity in vitro. Inhibition is noncompetitive with a Ki = 10-4 M. Similar inhibition occurs with D-ascorbate but not with dehydroascorbate or metabisulfite. The kinetics of inhibition by ascorbic acid were similar for “high” and “low” Km cAMP phosphodiesterase and cGMP phosphodiesterase activity.

Original languageEnglish (US)
Pages (from-to)534-536
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Sep 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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