Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

Pei Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan Ping Lee, Clara Li, Yian Gu, Jennifer S. Yokoyama, Dolly Reyes-Dumeyer, Yun Beom Choi, Hyun Sik Yang, Badri N. Vardarajan, Marian Tzuang, Kevin Lieu, Anna Lu, Kelley M. Faber, Zoë D. Potter, Carolyn Revta, Maureen Kirsch, Jake McCallum, Diana MeiBriana Booth, Laura B. Cantwell, Fangcong Chen, Sephera Chou, Dewi Clark, Michelle Deng, Ting Hei Hong, Ling Jen Hwang, Lilly Jiang, Yoonmee Joo, Younhee Kang, Ellen S. Kim, Hoowon Kim, Kyungmin Kim, Amanda B. Kuzma, Eleanor Lam, Serggio C. Lanata, Kunho Lee, Donghe Li, Mingyao Li, Xiang Li, Chia Lun Liu, Collin Liu, Linghsi Liu, Jody Lynn Lupo, Khai Nguyen, Shannon E. Pfleuger, James Qian, Winnie Qian, Veronica Ramirez, Kristen A. Russ, Eun Hyun Seo, Yeunjoo E. Song, Maria Carmela Tartaglia, Lu Tian, Mina Torres, Namkhue Vo, Ellen C. Wong, Yuan Xie, Eugene B. Yau, Isabelle Yi, Victoria Yu, Xiaoyi Zeng, Peter St George-Hyslop, Rhoda Au, Gerard D. Schellenberg, Jeffrey L. Dage, Rohit Varma, Ging Yuek R. Hsiung, Howard Rosen, Victor W. Henderson, Tatiana Foroud, Walter A. Kukull, Guerry M. Peavy, Haeok Lee, Howard H. Feldman, Richard Mayeux, Helena Chui, Gyungah R. Jun, Van M. Ta Park, Tiffany W. Chow, Li San Wang

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. METHODS: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. RESULTS: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. DISCUSSION: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. HIGHLIGHTS: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

Original languageEnglish (US)
Pages (from-to)2058-2071
Number of pages14
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 2024


  • Alzheimer's disease
  • Asian
  • biosamples
  • community-based participatory research
  • dementia
  • environmental
  • genetics

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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