Assembling anisotropic colloids using curvature-mediated lipid sorting

Manoj Kumar, Anupam Singh, Benedetta Del Secco, Maksim V. Baranov, Geert van den Bogaart, Stefano Sacanna, Shashi Thutupalli

Research output: Contribution to journalArticlepeer-review


The use of colloid supported lipid bilayers (CSLBs) for assembling colloidal structures has been of recent interest. Here, we use multi-component lipid bilayer membranes formed around anisotropic colloids and show that the curvature anisotropy of the colloids drives a sorting of the lipids in the membrane along the colloids. We then exploit this curvature-sensitive lipid sorting to create "shape-anisotropic patchy colloids" - specifically, we use colloids with six rods sticking out of a central cubic core, "hexapods", for this purpose and demonstrate that membrane patches self-assemble at the tip of each of the six colloidal rods. The membrane patches are rendered sticky using biotinylated lipids in complement with a biotin-binding streptavidin protein. Finally, using these "shape-anisotropic patchy colloids", we demonstrate the directed assembly of colloidal links, paving the way for the creation of heterogeneous and flexible colloidal structures.

Original languageEnglish (US)
Pages (from-to)1757-1766
Number of pages10
JournalSoft Matter
Issue number9
StatePublished - Mar 2 2022

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics


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