Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System

Moegammad A. Bardien; Alessandro Marone; Leila Khalili; Wei Tang; Stephen H.K. Kim; Anca D. Askanase; Andreas H. Hielscher

doi:10.1117/12.3043640

Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System

Moegammad A. Bardien, Alessandro Marone, Leila Khalili, Wei Tang, Stephen H.K. Kim, Anca D. Askanase, Andreas H. Hielscher

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A common symptom of systemic lupus erythematosus (SLE) is inflammation and joint pain in the fingers. There is currently no technology to objectively quantify the level of inflammation and monitor its progression over time. We evaluated the proximal interphalangeal (PIP) joints of two SLE subjects and two healthy subjects with a flexible optical imaging system (FOIS). FOIS includes eight sets of three light-emitting-diodes (LEDs) (wavelength λ = 880 nm, 660 nm, and 530 nm) and a photodiode to measure transmitted light from the LEDs by the photodetector. During data acquisition, a partial arterial occlusion is induced using a blood pressure cuff inflated to the subject’s diastolic blood pressure. The cuff is then released, and the measurement is allowed to return to baseline. The measurements are used to tomographically reconstruct the distribution of total hemoglobin concentrations (HbT) inside the finger. The SLE subjects’ PIPs were confirmed as diseased using systematic multiplanar grey-scale (GS) and power Doppler (PD) ultrasound. We found that the SLE subjects had a noticeably higher HbT in and around the joint cavities than in the healthy subjects. This suggests that FOIS could be used to assess inflammation in joints of SLE patients.

Original language	English (US)
Title of host publication	Optical Diagnostics and Sensing XXV
Subtitle of host publication	Toward Point-of-Care Diagnostics
Editors	Gerard L. Cote, Justin S. Justin S. Baba
Publisher	SPIE
ISBN (Electronic)	9781510683808
DOIs	https://doi.org/10.1117/12.3043640
State	Published - 2025
Event	Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics 2025 - San Francisco, United States Duration: Jan 27 2025 → Jan 28 2025

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	13316
ISSN (Print)	1605-7422

Conference

Conference	Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics 2025
Country/Territory	United States
City	San Francisco
Period	1/27/25 → 1/28/25

Keywords

hemoglobin reconstruction
SLE Arthritis
Systemic Lupus Erythematosus
wearables

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.3043640

Cite this

Bardien, M. A., Marone, A., Khalili, L., Tang, W., Kim, S. H. K., Askanase, A. D., & Hielscher, A. H. (2025). Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System. In G. L. Cote, & J. S. Justin S. Baba (Eds.), Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics Article 1331604 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13316). SPIE. https://doi.org/10.1117/12.3043640

Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System. / Bardien, Moegammad A.; Marone, Alessandro; Khalili, Leila et al.
Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. ed. / Gerard L. Cote; Justin S. Justin S. Baba. SPIE, 2025. 1331604 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13316).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bardien, MA, Marone, A, Khalili, L, Tang, W, Kim, SHK, Askanase, AD & Hielscher, AH 2025, Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System. in GL Cote & JS Justin S. Baba (eds), Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics., 1331604, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13316, SPIE, Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics 2025, San Francisco, United States, 1/27/25. https://doi.org/10.1117/12.3043640

Bardien MA, Marone A, Khalili L, Tang W, Kim SHK, Askanase AD et al. Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System. In Cote GL, Justin S. Baba JS, editors, Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. SPIE. 2025. 1331604. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3043640

Bardien, Moegammad A. ; Marone, Alessandro ; Khalili, Leila et al. / Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System. Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics. editor / Gerard L. Cote ; Justin S. Justin S. Baba. SPIE, 2025. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "A common symptom of systemic lupus erythematosus (SLE) is inflammation and joint pain in the fingers. There is currently no technology to objectively quantify the level of inflammation and monitor its progression over time. We evaluated the proximal interphalangeal (PIP) joints of two SLE subjects and two healthy subjects with a flexible optical imaging system (FOIS). FOIS includes eight sets of three light-emitting-diodes (LEDs) (wavelength λ = 880 nm, 660 nm, and 530 nm) and a photodiode to measure transmitted light from the LEDs by the photodetector. During data acquisition, a partial arterial occlusion is induced using a blood pressure cuff inflated to the subject{\textquoteright}s diastolic blood pressure. The cuff is then released, and the measurement is allowed to return to baseline. The measurements are used to tomographically reconstruct the distribution of total hemoglobin concentrations (HbT) inside the finger. The SLE subjects{\textquoteright} PIPs were confirmed as diseased using systematic multiplanar grey-scale (GS) and power Doppler (PD) ultrasound. We found that the SLE subjects had a noticeably higher HbT in and around the joint cavities than in the healthy subjects. This suggests that FOIS could be used to assess inflammation in joints of SLE patients.",

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AB - A common symptom of systemic lupus erythematosus (SLE) is inflammation and joint pain in the fingers. There is currently no technology to objectively quantify the level of inflammation and monitor its progression over time. We evaluated the proximal interphalangeal (PIP) joints of two SLE subjects and two healthy subjects with a flexible optical imaging system (FOIS). FOIS includes eight sets of three light-emitting-diodes (LEDs) (wavelength λ = 880 nm, 660 nm, and 530 nm) and a photodiode to measure transmitted light from the LEDs by the photodetector. During data acquisition, a partial arterial occlusion is induced using a blood pressure cuff inflated to the subject’s diastolic blood pressure. The cuff is then released, and the measurement is allowed to return to baseline. The measurements are used to tomographically reconstruct the distribution of total hemoglobin concentrations (HbT) inside the finger. The SLE subjects’ PIPs were confirmed as diseased using systematic multiplanar grey-scale (GS) and power Doppler (PD) ultrasound. We found that the SLE subjects had a noticeably higher HbT in and around the joint cavities than in the healthy subjects. This suggests that FOIS could be used to assess inflammation in joints of SLE patients.

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Assessing Inflammation in the Proximal Interphalangeal Joints of Systemic Lupus Erythematosus Patients with a Flexible Optical Imaging System

Abstract

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Conference

Keywords

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