TY - JOUR
T1 - Assessing the Relationship Between Central Corneal Thickness and Retinal Nerve Fiber Layer Thickness in Healthy Subjects
AU - Mumcuoglu, Tarkan
AU - Townsend, Kelly A.
AU - Wollstein, Gadi
AU - Ishikawa, Hiroshi
AU - Bilonick, Richard A.
AU - Sung, Kyung Rim
AU - Kagemann, Larry
AU - Schuman, Joel S.
N1 - Funding Information:
This study was supported in part by National Institutes of Health Grants R01-EY013178, R01-EY013516, and P30-EY008098, Bethesda, Maryland; The Eye and Ear Foundation, Pittsburgh, Pennsylvania; and an Unrestricted Grant from Research to Prevent Blindness Inc, New York, New York. Dr Schuman receives royalties for intellectual property licensed by Massachusetts Institute of Technology to Carl Zeiss Meditec. Dr Wollstein received research funding from Carl Zeiss Meditec and Optovue. Involved in design of study (T.M., G.W., J.S.S.); collection, management, analysis, and interpretation of data (T.M., K.A.T., G.W., H.I., R.A.B., K.R.S., L.K.); preparation of the manuscript (T.M., K.A.T., G.W.); and review of the manuscript (G.W., H.I., K.R.S., L.K., J.S.S.). The study followed the principles of the Declaration of Helsinki and Health Insurance Portability and Accountability Act regulations and received full Institutional Review Board and ethics committee approval by the University of Pittsburgh, University of Miami, and the University of Southern California, with informed consent obtained by all participants. ClinicalTrials.gov identifier: NCT00286637 .
PY - 2008/10
Y1 - 2008/10
N2 - Purpose: To determine the relationship between central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness obtained by scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Dublin, California, USA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany), and optical coherence tomography (Stratus OCT; Carl Zeiss Meditec). Design: Multicenter clinical trial, retrospective cross-sectional study. Methods: One hundred and nine healthy subjects from the Advanced Imaging in Glaucoma Study were enrolled in this study. All subjects had a standard clinical examination, including visual field (VF) and good-quality scans from all three imaging devices. CCT was measured using an ultrasonic pachymeter. A linear mixed-effects model was used to assess the relationship between RNFL thickness and CCT, accounting for clustering of eyes within subjects, testing site, ethnicity, family history of glaucoma, axial length intraocular pressure, and VF global indices. Results: For OCT and GDx, there was a slight nonstatistically significant positive relationship between CCT and RNFL thickness. For HRT, there was a slight nonstatistically significant negative relationship between CCT and RNFL thickness. Relationships for each device were found to differ between sites. Conclusions: CCT was not statistically significantly related to RNFL thickness in healthy eyes.
AB - Purpose: To determine the relationship between central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness obtained by scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Dublin, California, USA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany), and optical coherence tomography (Stratus OCT; Carl Zeiss Meditec). Design: Multicenter clinical trial, retrospective cross-sectional study. Methods: One hundred and nine healthy subjects from the Advanced Imaging in Glaucoma Study were enrolled in this study. All subjects had a standard clinical examination, including visual field (VF) and good-quality scans from all three imaging devices. CCT was measured using an ultrasonic pachymeter. A linear mixed-effects model was used to assess the relationship between RNFL thickness and CCT, accounting for clustering of eyes within subjects, testing site, ethnicity, family history of glaucoma, axial length intraocular pressure, and VF global indices. Results: For OCT and GDx, there was a slight nonstatistically significant positive relationship between CCT and RNFL thickness. For HRT, there was a slight nonstatistically significant negative relationship between CCT and RNFL thickness. Relationships for each device were found to differ between sites. Conclusions: CCT was not statistically significantly related to RNFL thickness in healthy eyes.
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U2 - 10.1016/j.ajo.2008.05.038
DO - 10.1016/j.ajo.2008.05.038
M3 - Article
C2 - 18657796
AN - SCOPUS:51849156324
SN - 0002-9394
VL - 146
SP - 561
EP - 566
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 4
ER -