Assessment of atmospheric pressure plasma treatment for implant osseointegration

Natalie R. Danna, Bryan G. Beutel, Nick Tovar, Lukasz Witek, Charles Marin, Estevam A. Bonfante, Rodrigo Granato, Marcelo Suzuki, Paulo G. Coelho

Research output: Contribution to journalArticle

Abstract

This study assessed the osseointegrative effects of atmospheric pressure plasma (APP) surface treatment for implants in a canine model. Control surfaces were untreated textured titanium (Ti) and calcium phosphate (CaP). Experimental surfaces were their 80-second air-based APP-treated counterparts. Physicochemical characterization was performed to assess topography, surface energy, and chemical composition. One implant from each control and experimental group (four in total) was placed in one radius of each of the seven male beagles for three weeks, and one implant from each group was placed in the contralateral radius for six weeks. After sacrifice, bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) were assessed. X-ray photoelectron spectroscopy showed decreased surface levels of carbon and increased Ti and oxygen, and calcium and oxygen, posttreatment for Ti and CaP surfaces, respectively. There was a significant (P<0.001) increase in BIC for APP-treated textured Ti surfaces at six weeks but not at three weeks or for CaP surfaces. There were no significant (P=0.57) differences for BAFO between treated and untreated surfaces for either material at either time point. This suggests that air-based APP surface treatment may improve osseointegration of textured Ti surfaces but not CaP surfaces. Studies optimizing APP parameters and applications are warranted.

Original languageEnglish (US)
Article number761718
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Danna, N. R., Beutel, B. G., Tovar, N., Witek, L., Marin, C., Bonfante, E. A., Granato, R., Suzuki, M., & Coelho, P. G. (2015). Assessment of atmospheric pressure plasma treatment for implant osseointegration. BioMed Research International, 2015, [761718]. https://doi.org/10.1155/2015/761718